Nicholas Brown

Has grant

Assistant Professor

University of North Carolina

United States

Research Interests

Explore related searches

Professors in United States Professors in Molecular Biology Molecular Biology professors in United States

Contact this professor

Get a free first email built on one of their papers, ready for you to edit and send yourself.

About

Nicholas Brown is an Assistant Professor at the University of North Carolina, USA. His research focuses on the biology of cell cycle regulation, ubiquitin ligases, and deubiquitinases, as evidenced by his recent articles examining mechanisms of APC/C inactivation and the role of TET2 in tumor antigen presentation. He also investigates the proteomic implications of mitotic transitions and the recruitment of E3 ligases in cellular processes.

Recent Grants

Grant: Close

DISSECTING MACROMOLECULAR COMPLEXES OF PROTEIN QUALITY CONTROL IN THE HEART

Open Date: 2023-07-01

Close Date: 2025-06-30

Articles (21)

Year:

2025

Year:

2025

Year:

2025

Year:

2025

Year:

2024

Year:

2024

Year:

2024

Year:

2024

Year:

2024

Year:

2024

Year:

2023

Year:

2023

Year:

2023

Year:

2023

Year:

2023

Year:

2022

Year:

2022

Year:

2022

Year:

2022

Year:

2022

Year:

2021

Collaborators (6)

Qi Zhang

Associate Professor

University of North Carolina at Chapel Hill

UNITED STATES

View details

Klaus Hahn

University of North Carolina at Chapel Hill

UNITED STATES

View details

Joseph Harrison

Assistant Professor

University of the Pacific

UNITED STATES

View details

Alexander Schleiffer

AUSTRIA

View details

Richard Page

Associate Professor and Assistant Chair

University of Miami

UNITED STATES

View details

Purvi Patel

Vanderbilt University

UNITED STATES

View details

ApplyKite TwinLearns as you apply

Make your next move.

Prepare your application

Review drafts before you send them.

Nicholas Brown

Research Interests

Explore related searches

Contact this professor

About

Recent Grants

Articles (21)

Transient APC/C inactivation by mTOR boosts glycolysis during cell cycle entry.

Mechanisms of USP18 specificity toward ISG15 revealed by paralog sequence analysis comparison

USP37 prevents unscheduled replisome unloading through MCM complex deubiquitination

APC/C-mediated ubiquitylation of extranucleosomal histone complexes lacking canonical degrons.

Friend or foe? Reciprocal regulation between E3 ubiquitin ligases and deubiquitinases

Multi-monoubiquitylation controls VASP-mediated actin dynamics

TET2 promotes tumor antigen presentation and T cell IFN-γ, which is enhanced by vitamin C.

Proteomic analysis reveals a PLK1-dependent G2/M degradation program and a role for AKAP2 in coordinating the mitotic cytoskeleton.

Recruitment of FBXO22 for targeted degradation of NSD2.

A structure-based designed small molecule depletes hRpn13Pru and a select group of KEN box proteins

Dosage sensitivity to Pumilio1 variants in the mouse brain reflects distinct molecular mechanisms

Cryo‐EM structure of the chain‐elongating E3 ubiquitin ligase UBR5

AtomNet-Aided OTUD7B Inhibitor Discovery and Validation

Enabling Genetic Code Expansion and Peptide Macrocyclization in mRNA Display via a Promiscuous Orthogonal Aminoacyl-tRNA Synthetase.

Time-resolved cryo-EM (TR-EM) analysis of substrate polyubiquitination by the RING E3 anaphase-promoting complex/cyclosome (APC/C)

The molecular basis of spinocerebellar ataxia type 48 caused by a de novo mutation in the ubiquitin ligase CHIP

Frozen in time: analyzing molecular dynamics with time-resolved cryo-EM.

Insight into Viral Hijacking of CRL4 Ubiquitin Ligase through Structural Analysis of the pUL145-DDB1 Complex

Examining the mechanistic relationship of APC/CCDH1 and its interphase inhibitor EMI1

Cryo-EM structure of the plant 26S proteasome.

Functional conservation and divergence of the helix-turn-helix motif of E2 ubiquitin-conjugating enzymes.

Collaborators (6)

Qi Zhang

Klaus Hahn

Joseph Harrison

Alexander Schleiffer

Richard Page

Purvi Patel

Make your next move.