Nicholas Chavkin

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Assistant Professor

University of Washington

United States

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About

Nicholas Chavkin is an Assistant Professor at the University of Washington, USA. His research primarily focuses on hematopoiesis, endothelial cell biology, and the implications of genetic anomalies in diseases such as cardiac amyloidosis and heart failure. Recent publications explore topics including the impact of Y chromosome loss on immune checkpoints and the effects of obesogenic diets on mitochondrial gene expression in endothelial tissue.

Recent Grants

Grant: Close

Age-Related Loss of the Y Chromosome in Heart Failure

Open Date: 2023-06-01

Close Date: 2026-05-31

Articles (11)

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2025

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2024

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2024

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2024

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2023

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2023

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2023

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2023

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UNITED STATES

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Lars Forsberg

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Uppsala University

SWEDEN

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Nicholas Chavkin

Research Interests

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About

Recent Grants

Articles (11)

Hematopoietic loss of Y chromosome activates immune checkpoints and contributes to impaired senescent cell clearance and renal disease

Obesogenic diet disrupts tissue-specific mitochondrial gene signatures in the artery and capillary endothelium

Mosaic Loss of the Y Chromosome Is Enriched in Patients With Wild-Type Transthyretin Cardiac Amyloidosis and Associated With Increased Mortality

Induced Endothelial Cell Cycle Arrest Prevents Arteriovenous Malformations in Hereditary Hemorrhagic Telangiectasia

Disruption of the Uty epigenetic regulator locus in hematopoietic cells phenocopies the profibrotic attributes of Y chromosome loss in heart failure

How clonal hematopoiesis promotes inflammation at a single-cell level

Connexin 37 sequestering of activated-ERK in the cytoplasm promotes p27-mediated endothelial cell cycle arrest

Clonal Hematopoiesis in Clinical and Experimental Heart Failure With Preserved Ejection Fraction

SLC20a1/PiT-1 is required for chorioallantoic placental morphogenesis

Endothelial cell cycle state determines propensity for arterial-venous fate

Hematopoietic loss of Y chromosome leads to cardiac fibrosis and heart failure mortality.

Collaborators (7)

Vlad Serbulea

Miriam Cortese-Krott

Kenneth Walsh

Gael GENET

Ariel Polizio

Karen K Hirschi

Lars Forsberg

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