Nicholas Tolwinski

Associate Professor

Duke-NUS Medical School

Singapore

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About

Dr. Nicholas Tolwinski is an Associate Professor at Duke NUS Graduate Medical School in Singapore. His research focuses on developmental biology, neurogenesis, and aging, with recent publications exploring topics such as aging clocks, Alzheimer’s disease modeling, and centrosomal proteins. Dr. Tolwinski’s work integrates optogenetic techniques and high-throughput drug screening to identify potential therapeutic targets for neurological conditions.

Articles (12)

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2024

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2024

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2024

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2023

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2022

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2022

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2021

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2021

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2020

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2020

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2020

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2020

Collaborators (3)

Ajay S. Mathuru

Associate Professor

National University of Singapore (NUS)

SINGAPORE

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NATHAN HARMSTON

Lecturer

Cardiff University

UNITED KINGDOM

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Gavin Dawe

Associate Professor and Head of Department

National University of Singapore

SINGAPORE

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Nicholas Tolwinski

Research Interests

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About

Articles (12)

The Wnt Co-Receptor PTK7/Otk and Its Homolog Otk-2 in Neurogenesis and Patterning

Principal component-based clinical aging clocks identify signatures of healthy aging and targets for clinical intervention

Drosophila—A Model System for Developmental Biology

Using Optogenetics to Model Cellular Effects of Alzheimer’s Disease

MCC is a centrosomal protein that relocalizes to non-centrosomal apical sites during intestinal cell differentiation

Wnt Signaling Rescues Amyloid Beta-Induced Gut Stem Cell Loss

Optogenetic approaches for understanding homeostatic and degenerative processes in Drosophila

Shared signaling pathways in Alzheimer’s and metabolic disease may point to new treatment approaches

Application of optogenetic Amyloid-β distinguishes between metabolic and physical damages in neurodegeneration

A high throughput drug screening paradigm using transgenic Caenorhabditis elegans model of Alzheimer’s disease

An Optogenetic Method to Study Signal Transduction in Intestinal Stem Cell Homeostasis.

Drug synergy as a strategy for compression of morbidity in a Caenorhabditis elegans model of Alzheimer's disease.

Collaborators (3)

Ajay S. Mathuru

NATHAN HARMSTON

Gavin Dawe

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