Nick Peake
Senior Lecturer in Biomedical Sciences
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About
Nick Peake is a Senior Lecturer in Biomedical Sciences at Sheffield Hallam University, United Kingdom. His research focuses on the role of extracellular vesicles in cancer progression and therapeutic delivery, with a particular interest in colorectal cancer. He has published recent articles on topics including selective autophagy in hepatic diseases and the characterization of extracellular vesicle proteins using advanced imaging techniques.
Positions (2)
Nick Peake
Sheffield Hallam University
Two exciting PhD opportunities are available in the field of extracellular vesicles (EVs) through the BBSRC Yorkshire Bioscience Doctoral Training Partnership (YBDTP). These projects are collaborative efforts between Sheffield Hallam University and the University of Sheffield, focusing on cutting-edge research topics such as cross-kingdom communication and single EV detection. The research aims to advance our understanding of EV biology, with potential applications in biotechnology, molecular biology, and biomedical sciences. The YBDTP brings together leading bioscience research across Yorkshire and Teesside, supported by the Biotechnology and Biological Sciences Research Council (BBSRC) and partner universities. The program is designed to train the next generation of bioscientists, equipping them with skills for careers in academia, industry, policy, and civil society. Students will benefit from access to centres of excellence, industry collaborations, and expert supervision. Applicants should have a strong background in biology, biomedical sciences, or a related field, and an interest in extracellular vesicle biology or single molecule detection. The studentships are fully funded for eligible UK students, covering tuition fees and a stipend at the UKRI rate. For more information on the projects and application process, visit the YBDTP website or the FindAPhD project page. Interested candidates are encouraged to contact the supervisors for further details.
Nick Peake
Sheffield Hallam University
1 year ago
<p>Two fully funded PhD opportunities are available in the field of extracellular vesicle (EV) biology, focusing on cross-kingdom communication and single EV detection. These positions are offered through the BBSRC Yorkshire Bioscience Doctoral Training Partnership (YBDTP), a collaboration between leading universities in Yorkshire, including Sheffield Hallam University and the University of Sheffield.</p><p>The YBDTP brings together world-class research in biosciences and biotechnology, aiming to train the next generation of bioscientists for careers in academia, industry, policy, and civil society. The partnership is supported by the Biotechnology and Biological Sciences Research Council (BBSRC) and includes multiple partner universities across the region.</p><p>Successful candidates will join a vibrant research community and benefit from extensive industry collaboration, expert supervision, and access to state-of-the-art facilities. The projects will explore innovative aspects of EV biology, with a particular emphasis on cross-kingdom communication and advanced detection methods for single EVs.</p><p>Applicants should hold or expect to achieve a good honours degree in a relevant bioscience or related discipline. A keen interest in EV biology and related research areas is essential. The positions are fully funded, covering tuition fees and providing a stipend at the UKRI standard rate. Additional training and research support are available.</p><p>To apply, visit the Yorkshire Bioscience DTP website to browse available projects and follow the application instructions. For further information or project-specific enquiries, contact the supervisors directly. The application deadline is December 28, 2024.</p>
1 year ago
Articles (5)
Extracellular vesicles (EVs) are lipid bilayer structures released by all cells that mediate cell-to-cell communication via the transfer of bioactive cargo. Because of the natural origin of EVs, their efficient uptake by recipient cells, capacity to stabilize and transport biomolecules and their potential for cell/tissue targeting and preferential uptake by cancer cells, they have enormous potential for bioengineering into improved and targeted drug delivery systems. In this work, we investigated the use of laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) as a tool to measure the loading of platinum-based chemotherapeutic agents. The EV loading of oxaliplatin via co-incubation was demonstrated, and LA-ICP-MS imaging showed greater efficiency of delivery to colorectal cancer cells compared to free oxaliplatin, leading to enhanced cytotoxic effect. Further, the impact of EV co-loading with a porphyrin (C5SHU, known as ‘C5’) photosensitizer on oxaliplatin delivery was assessed. Fluorescence analysis using nano-flow cytometry showed dose-dependent EV loading as well as a trend towards the loading of larger particles. Exposure of OXA-C5-EV-treated colorectal cancer cells to light indicated that delivery was enhanced by both light exposure and porphyrins, with a synergistic effect on cell viability observed between oxaliplatin, EVs and light exposure after the delivery of the co-loaded EVs. In summary, this work demonstrates the utility of LA-ICP-MS and mass spectrometry imaging in assessing the loading efficiency and cellular delivery of platinum-based therapeutics, which would also be suitable for agents containing other elements, confirms that EVs are more efficient at delivery compared to free drugs, and describes the use of light exposure in optimizing delivery and therapeutic effects of EV-mediated drug delivery both in combination and independently of porphyrin-based photosensitizers.
Year:
2023
Year:
2023
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2023
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2022
Year:
2021
Collaborators (2)
Owen Davies
Senior Lecturer (Associate Professor)
Loughborough University
Christine Le Maitre
Professor of Musculoskeletal Cell Biology and Tissue Regeneration
The University of Sheffield - The Edge
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