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Nicola Pozzi

Associate Professor

Saint Louis University

United States

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Research Interests

Biochemistry

90%

Cell Biology

50%

Protein Chemistry

40%

Allosteric Regulation

30%

Thrombosis

20%

Rna Biology

20%

Membrane Protein

20%

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Recent Grants

Grant: Close

Structural studies of beta-2 glycoprotein I in the Antiphospholipid Syndrome

Open Date: 2019-12-01

Close Date: 2024-12-01

Grant: Close

Hepatitis B virus ribonuclease H: Mechanisms of catalysis and inhibition

Open Date: 2018-08-01

Close Date: 2021-07-01

Grant: Close

Autoimmunity: Structural Studies on the Mechanisms of Antigen-Antibody Recognition in the Antiphospholipid Syndrome.

Open Date: 2017-05-01

Close Date: 2018-10-01

Grant: Close

Structure-Based Mechanism for Prothrombin Activation by the Prothrombinase Complex

Open Date: 2015-07-01

Close Date: 2018-06-01

Articles27

Lupus anticoagulant and antiprothrombin antibodies: embracing the future

Article Link

Year:

2025

Antiphospholipid IgG Certified Reference Material ERM®-DA477/IFCC: a tool for aPL harmonization?

Article Link

Year:

2025

N-glycosylation in the SERPIN domain of the C1-esterase inhibitor in hereditary angioedema.

Article Link

Year:

2025

Atomistic characterization of β2-glycoprotein I domain V interaction with anionic membranes

Article Link

Year:

2024

Illustrated State-of-the-Art Capsules of the ISTH 2024 Congress.

Article Link

Year:

2024

The strand exchange domain of tumor suppressor PALB2 is intrinsically disordered and promotes oligomerization-dependent DNA compaction

Article Link

Year:

2024

Mechanistic basis of activation and inhibition of protein disulfide isomerase by allosteric antithrombotic compounds.

Article Link

Year:

2024

Understanding the difference between type I and type II antiprothrombin antibodies and their effect on activated protein C resistance.

Article Link

Year:

2024

Cryo-EM structure and functional basis of prothrombin recognition by a type I antiprothrombin antiphospholipid antibody.

Article Link

Year:

2024

Dynamic states of eIF6 and SDS variants modulate interactions with uL14 of the 60S ribosomal subunit

Article Link

Year:

2023

From haemadin to haemanorm: Synthesis and characterization of full‐length haemadin from the leech Haemadipsa sylvestris and of a novel bivalent, highly potent thrombin inhibitor (haemanorm)

Article Link

Year:

2023

Homodimeric Granzyme A Opsonizes Mycobacterium tuberculosis and Inhibits Its Intracellular Growth in Human Monocytes via Toll-Like Receptor 4 and CD14

Article Link

Year:

2023

Mutations in atypical hemolytic uremic syndrome provide evidence for the role of calcium in complement factor I.

Article Link

Year:

2023

Structural analyses of β2-glycoprotein I: is there a circular conformation?

Article Link

Year:

2023

Probing the conformational dynamics of thiol-isomerases using non-canonical amino acids and single-molecule FRET.

Article Link

Year:

2023

Sulfenylation links oxidative stress to protein disulfide isomerase oxidase activity and thrombus formation.

Article Link

Year:

2023

Reduction of protein disulfide isomerase results in open conformations and stimulates dynamic exchange between structural ensembles.

Article Link

Year:

2022

Functional Analysis of Rare Genetic Variants in Complement Factor I (CFI) in Advanced Age-related Macular Degeneration (AMD).

Article Link

Year:

2022

Post-Transplant Thrombotic Microangiopathy due to a Pathogenic Mutation in Complement Factor I in a Patient With Membranous Nephropathy: Case Report and Review of Literature.

Article Link

Year:

2022

Alpha-hydroxytropolones are noncompetitive inhibitors of human RNase H1 that bind to the active site and modulate substrate binding.

Article Link

Year:

2022

Discovery of novel N-acylpyrazoles as potent and selective thrombin inhibitors.

Article Link

Year:

2022

A Novel ELISA Assay for the Detection of Anti-Prothrombin Antibodies in Antiphospholipid Syndrome Patients at High Risk of Thrombosis.

Article Link

Year:

2021

Granzyme A Produced by γ9δ2 T Cells Activates ER Stress Responses and ATP Production, and Protects Against Intracellular Mycobacterial Replication Independent of Enzymatic Activity.

Article Link

Year:

2021

Multiple-Organ Complement Deposition on Vascular Endothelium in COVID-19 Patients

Article Link

Year:

2021

An allosteric redox switch in domain V of β2-glycoprotein I controls membrane binding and anti-domain I autoantibody recognition.

Article Link

Year:

2021

Development of Nanosilicate-Hydrogel Composites for Sustained Delivery of Charged Biopharmaceutics.

Article Link

Year:

2021

Anti-Phospholipid Antibodies in COVID-19 Are Different From Those Detectable in the Anti-Phospholipid Syndrome.

Article Link

Year:

2020

Collaborators19

Angela TINCANI

University of Brescia

ITALY

Carsten Deppermann

Assistant Professor (Tenure Track)

Johannes Gutenberg Universität Mainz

GERMANY

Paolo Durigutto

Professional Biologist

Istituto Auxologico Italiano Istituto di Ricovero e Cura a Carattere Scientifico

ITALY

Emad Tajkhorshid

Professor of Biochemistry, Chemistry, Biophysics, Bioengineering, and Computational Science and Engineering

University of Illinois at Urbana-Champaign

UNITED STATES

Sarah Walker

Assistant Professor

State University of New York at Buffalo

UNITED STATES

Philip Hogg

Professor of Protein Science

University of Sydney

AUSTRALIA

Sana Shaikh

university of california davis medical center

UNITED STATES

José Rivera

SPAIN

Daniel F Hoft

Saint Louis University School of Medicine

UNITED STATES

Sergey Korolev

Associate Professor

Saint Louis University School of Medicine

UNITED STATES

Anuja Java

Washington University in St. Louis

UNITED STATES

John E. Tavis

UNITED STATES

Andrea Pierangelini

University of Oxford

UNITED KINGDOM

Paolo Macor

University of Trieste

ITALY

Vincenzo De Filippis

ITALY

Anirban Datta

Head of Biology

Visteon Corporation

UNITED STATES

Michael Walch

Full professor

University of Fribourg

SWITZERLAND

Chris Eickhoff

Associate Research Professor

Saint Louis University

UNITED STATES

Vittorio Pengo

Associate Professor of Cardiology

University of Padua

ITALY

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Nicola Pozzi

Associate Professor

How do I reach out?

Contact this professor

Research Interests

Ask ApplyKite AI

Recent Grants

Articles27

Lupus anticoagulant and antiprothrombin antibodies: embracing the future

Antiphospholipid IgG Certified Reference Material ERM®-DA477/IFCC: a tool for aPL harmonization?

N-glycosylation in the SERPIN domain of the C1-esterase inhibitor in hereditary angioedema.

Atomistic characterization of β2-glycoprotein I domain V interaction with anionic membranes

Illustrated State-of-the-Art Capsules of the ISTH 2024 Congress.

The strand exchange domain of tumor suppressor PALB2 is intrinsically disordered and promotes oligomerization-dependent DNA compaction

Mechanistic basis of activation and inhibition of protein disulfide isomerase by allosteric antithrombotic compounds.

Understanding the difference between type I and type II antiprothrombin antibodies and their effect on activated protein C resistance.

Cryo-EM structure and functional basis of prothrombin recognition by a type I antiprothrombin antiphospholipid antibody.

Dynamic states of eIF6 and SDS variants modulate interactions with uL14 of the 60S ribosomal subunit

From haemadin to haemanorm: Synthesis and characterization of full‐length haemadin from the leech <i>Haemadipsa sylvestris</i> and of a novel bivalent, highly potent thrombin inhibitor (haemanorm)

Homodimeric Granzyme A Opsonizes <i>Mycobacterium tuberculosis</i> and Inhibits Its Intracellular Growth in Human Monocytes via Toll-Like Receptor 4 and CD14

Mutations in atypical hemolytic uremic syndrome provide evidence for the role of calcium in complement factor I.

Structural analyses of β<sub>2</sub>-glycoprotein I: is there a circular conformation?

Probing the conformational dynamics of thiol-isomerases using non-canonical amino acids and single-molecule FRET.

Sulfenylation links oxidative stress to protein disulfide isomerase oxidase activity and thrombus formation.

Reduction of protein disulfide isomerase results in open conformations and stimulates dynamic exchange between structural ensembles.

Functional Analysis of Rare Genetic Variants in Complement Factor I (CFI) in Advanced Age-related Macular Degeneration (AMD).

Post-Transplant Thrombotic Microangiopathy due to a Pathogenic Mutation in Complement Factor I in a Patient With Membranous Nephropathy: Case Report and Review of Literature.

Alpha-hydroxytropolones are noncompetitive inhibitors of human RNase H1 that bind to the active site and modulate substrate binding.

Discovery of novel N-acylpyrazoles as potent and selective thrombin inhibitors.

A Novel ELISA Assay for the Detection of Anti-Prothrombin Antibodies in Antiphospholipid Syndrome Patients at High Risk of Thrombosis.

Granzyme A Produced by γ<sub>9</sub>δ<sub>2</sub> T Cells Activates ER Stress Responses and ATP Production, and Protects Against Intracellular Mycobacterial Replication Independent of Enzymatic Activity.

Multiple-Organ Complement Deposition on Vascular Endothelium in COVID-19 Patients

An allosteric redox switch in domain V of β<sub>2</sub>-glycoprotein I controls membrane binding and anti-domain I autoantibody recognition.

Development of Nanosilicate-Hydrogel Composites for Sustained Delivery of Charged Biopharmaceutics.

Anti-Phospholipid Antibodies in COVID-19 Are Different From Those Detectable in the Anti-Phospholipid Syndrome.

Collaborators19

Angela TINCANI

Carsten Deppermann

Paolo Durigutto

Emad Tajkhorshid

Sarah Walker

Philip Hogg

Sana Shaikh

José Rivera

Daniel F Hoft

Sergey Korolev

Anuja Java

John E. Tavis

Andrea Pierangelini

Paolo Macor

Vincenzo De Filippis

Anirban Datta

Michael Walch

Chris Eickhoff

Vittorio Pengo

How do I reach out?