Nicola Pozzi

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Associate Professor

Saint Louis University

United States

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About

Nicola Pozzi is an Associate Professor at Saint Louis University, USA. His research focuses on anticoagulant mechanisms, protein interactions, and the role of antibodies in thrombotic disorders, as reflected in his recent publications. Notable works include investigations on lupus anticoagulant, N-glycosylation in hereditary angioedema, and the structural basis of prothrombin recognition by antibodies.

Recent Grants

Grant: Close

Structural studies of beta-2 glycoprotein I in the Antiphospholipid Syndrome

Open Date: 2019-12-01

Close Date: 2024-12-01

Grant: Close

Hepatitis B virus ribonuclease H: Mechanisms of catalysis and inhibition

Open Date: 2018-08-01

Close Date: 2021-07-01

Grant: Close

Autoimmunity: Structural Studies on the Mechanisms of Antigen-Antibody Recognition in the Antiphospholipid Syndrome.

Open Date: 2017-05-01

Close Date: 2018-10-01

Grant: Close

Structure-Based Mechanism for Prothrombin Activation by the Prothrombinase Complex

Open Date: 2015-07-01

Close Date: 2018-06-01

Articles (27)

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2025

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2021

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2021

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2021

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2021

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2020

Collaborators (19)

Angela TINCANI

University of Brescia

ITALY

Nicola Pozzi

Research Interests

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About

Recent Grants

Articles (27)

Lupus anticoagulant and antiprothrombin antibodies: embracing the future

Antiphospholipid IgG Certified Reference Material ERM®-DA477/IFCC: a tool for aPL harmonization?

N-glycosylation in the SERPIN domain of the C1-esterase inhibitor in hereditary angioedema.

Atomistic characterization of β2-glycoprotein I domain V interaction with anionic membranes

Illustrated State-of-the-Art Capsules of the ISTH 2024 Congress.

The strand exchange domain of tumor suppressor PALB2 is intrinsically disordered and promotes oligomerization-dependent DNA compaction

Mechanistic basis of activation and inhibition of protein disulfide isomerase by allosteric antithrombotic compounds.

Understanding the difference between type I and type II antiprothrombin antibodies and their effect on activated protein C resistance.

Cryo-EM structure and functional basis of prothrombin recognition by a type I antiprothrombin antiphospholipid antibody.

Dynamic states of eIF6 and SDS variants modulate interactions with uL14 of the 60S ribosomal subunit

From haemadin to haemanorm: Synthesis and characterization of full‐length haemadin from the leech <i>Haemadipsa sylvestris</i> and of a novel bivalent, highly potent thrombin inhibitor (haemanorm)

Homodimeric Granzyme A Opsonizes <i>Mycobacterium tuberculosis</i> and Inhibits Its Intracellular Growth in Human Monocytes via Toll-Like Receptor 4 and CD14

Mutations in atypical hemolytic uremic syndrome provide evidence for the role of calcium in complement factor I.

Structural analyses of β<sub>2</sub>-glycoprotein I: is there a circular conformation?

Probing the conformational dynamics of thiol-isomerases using non-canonical amino acids and single-molecule FRET.

Sulfenylation links oxidative stress to protein disulfide isomerase oxidase activity and thrombus formation.

Reduction of protein disulfide isomerase results in open conformations and stimulates dynamic exchange between structural ensembles.

Functional Analysis of Rare Genetic Variants in Complement Factor I (CFI) in Advanced Age-related Macular Degeneration (AMD).

Post-Transplant Thrombotic Microangiopathy due to a Pathogenic Mutation in Complement Factor I in a Patient With Membranous Nephropathy: Case Report and Review of Literature.

Alpha-hydroxytropolones are noncompetitive inhibitors of human RNase H1 that bind to the active site and modulate substrate binding.

Discovery of novel N-acylpyrazoles as potent and selective thrombin inhibitors.

A Novel ELISA Assay for the Detection of Anti-Prothrombin Antibodies in Antiphospholipid Syndrome Patients at High Risk of Thrombosis.

Granzyme A Produced by γ<sub>9</sub>δ<sub>2</sub> T Cells Activates ER Stress Responses and ATP Production, and Protects Against Intracellular Mycobacterial Replication Independent of Enzymatic Activity.

Multiple-Organ Complement Deposition on Vascular Endothelium in COVID-19 Patients

An allosteric redox switch in domain V of β<sub>2</sub>-glycoprotein I controls membrane binding and anti-domain I autoantibody recognition.

Development of Nanosilicate-Hydrogel Composites for Sustained Delivery of Charged Biopharmaceutics.

Anti-Phospholipid Antibodies in COVID-19 Are Different From Those Detectable in the Anti-Phospholipid Syndrome.

Collaborators (19)

Angela TINCANI

Carsten Deppermann

Paolo Durigutto

Emad Tajkhorshid

Sarah Walker

Philip Hogg

Sana Shaikh

José Rivera

Daniel F Hoft

Sergey Korolev

Anuja Java

John E. Tavis

Andrea Pierangelini

Paolo Macor

Vincenzo De Filippis

Anirban Datta

Michael Walch

Chris Eickhoff

Vittorio Pengo

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