Nicole Borth

Professor

Universität für Bodenkultur Wien

Austria

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Professor Nicole Borth is a faculty member at Universität für Bodenkultur Wien, Austria. Her research primarily focuses on the optimization of gene expression and productivity in Chinese hamster ovary (CHO) cells, with recent publications addressing gene integration, transcriptomic responses, and targeted sequencing techniques. Professor Borth's work contributes significantly to advancements in bioprocessing and biopharmaceutical development.

Articles (13)

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2025

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2025

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2024

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2023

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2023

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2023

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2023

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2022

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2022

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2021

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2021

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2021

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2021

Collaborators (4)

scott tenenbaum

Associate Professor 10 Months

University at Albany, State University of New York

UNITED STATES

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Andreas Bernhard Diendorfer

Head of Computational Biology

AUSTRIA

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Susan Sharfstein

Professor 10 Months

University at Albany, State University of New York

UNITED STATES

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Nicolas Marx

AUSTRIA

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Nicole Borth

Research Interests

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Articles (13)

Stepwise activation of gene copies results in higher final titers of subclones compared to immediate integration of the full set of active copies

Fantastic genes and where to find them expressed in CHO

Combined approach of selective and accelerated cloning for microfluidic chip‐based system increases clone specific productivity

Nanopore Cas9‐targeted sequencing enables accurate and simultaneous identification of transgene integration sites, their structure and epigenetic status in recombinant Chinese hamster ovary cells

LncRNA analysis of mAb producing CHO clones reveals marker and engineering potential

SLAM‐seq reveals early transcriptomic response mechanisms upon glutamine deprivation in Chinese hamster ovary cells

Single-cell RNA sequencing reveals homogeneous transcriptome patterns and low variance in a suspension CHO-K1 and an adherent HEK293FT cell line in culture conditions

In silico design of CMV promoter binding oligonucleotides and their impact on inhibition of gene expression in Chinese hamster ovary cells

Codon and signal peptide optimization for therapeutic antibody production from Chinese hamster ovary (CHO) cell

PTSelect™: A post-transcriptional technology that enables rapid establishment of stable CHO cell lines and surveillance of clonal variation

Enhanced targeted DNA methylation of the CMV and endogenous promoters with dCas9-DNMT3A3L entails distinct subsequent histone modification changes in CHO cells

Subcloning induces changes in the DNA‐methylation pattern of outgrowing Chinese hamster ovary cell colonies

Error propagation in constraint‐based modeling of Chinese hamster ovary cells

Collaborators (4)

scott tenenbaum

Andreas Bernhard Diendorfer

Susan Sharfstein

Nicolas Marx

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