Nicole Déglon

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Associate Professor

Lausanne University Hospital (CHUV)

Switzerland

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About

Nicole Déglon is an Associate Professor at Lausanne University Hospital (CHUV) in Switzerland. Her research focuses on neurodegenerative diseases, particularly Huntington's disease and spinocerebellar ataxia, with recent publications exploring gene editing strategies and the effects of tau pathology on neuronal dynamics. She employs innovative approaches such as CRISPR technology and patient-specific induced pluripotent stem cells to advance therapeutic understanding and outcomes in these conditions.

Recent Grants

Grant: Close

Toward gene repair for Huntington’s disease

Open Date: 2019-06-01

Close Date: 2023-05-01

Grant: Close

KamiCa9 Inactivation of WT HTT in Rodent

Open Date: 2018-11-01

Close Date: 2021-04-01

Grant: Close

Toward gene repair for CNS genetic disorders

Open Date: 2018-07-01

Close Date: 2020-06-01

Grant: Close

Allele-specific lowering of mutant polyQ proteins as treatment for Huntington disease, spinocerebellar ataxia type 3 and spinocerebellar ataxia type 7

Open Date: 2018-03-01

Close Date: 2021-02-01

Grant: Close

Gene editing for Huntington's disease

Open Date: 2016-04-01

Close Date: 2019-03-01

Articles (17)

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2022

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2021

Collaborators (13)

Marina Rubio

INSERM

FRANCE

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bruno lefebvre

associate professor

FRANCE

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Yannick Vermeiren

Guest Professor

University of Antwerp

BELGIUM

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Morvane Colin

Assistant Professor

Université de Lille

FRANCE

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Victoria Gómez Murcia

Profesor Ayudante Doctor (Assistant Professor)

Universidad de Murcia

SPAIN

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Stephanie Schorge

Professor

UNITED KINGDOM

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Kevin Richetin

SWITZERLAND

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Julien Puyal

SWITZERLAND

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Devrim Kilinc

Institut Pasteur de Lille

FRANCE

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Corrado Calì

Assistant professor

University of Turin

ITALY

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Nicolas Toni

Professeur Associé

SWITZERLAND

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Paola Bezzi

SWITZERLAND

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Sylvain Perriot

Lausanne University Hospital

SWITZERLAND

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Nicole Déglon

Research Interests

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About

Recent Grants

Articles (17)

Selective striatal pathological changes in a novel human HTT exon 1 knock-in mouse model of Huntington's disease

Gene editing for Spinocerebellar ataxia type 3 taking advantage of the human ATXN3L paralog as replacement gene

Extracellular PHF-tau modulates astrocyte mitochondrial dynamics and mediates neuronal connectivity.

Neuronal A2A receptor exacerbates synapse loss and memory deficits in APP/PS1 mice

Gene editing as a therapeutic strategy for spinocerebellar ataxia type-3

Mono- and Biallelic Inactivation of Huntingtin Gene in Patient-Specific Induced Pluripotent Stem Cells Reveal HTT Roles in Striatal Development and Neuronal Functions

Tau Transfer via Extracellular Vesicles Disturbs the Astrocytic Mitochondrial System

Limitations of dual-sgRNA CRISPR strategies for the treatment of CNS genetic disorders

Semi-automated workflows to quantify AAV transduction in various brain areas and predict gene editing outcome for neurological disorders

Disruption of astrocyte-dependent dopamine control in the developing medial prefrontal cortex leads to excessive grooming in mice

Revisiting the outcome of adult wild-type Htt inactivation in the context of HTT-lowering strategies for Huntington’s disease

Tau promotes oxidative stress-associated cycling neurons in S phase as a pro-survival mechanism: possible implication for Alzheimer’s disease

Central Nervous System Gene Therapy: Present Developments and Emerging Trends Accelerating Industry-Academia Pathways

Correction: Maximizing lentiviral vector gene transfer in the CNS

Extracellular vesicles: Major actors of heterogeneity in tau spreading among human tauopathies

Thrombolysis by PLAT/tPA increases serum free IGF1 leading to a decrease of deleterious autophagy following brain ischemia.

Lactate transporters in the rat barrel cortex sustain whisker-dependent BOLD fMRI signal and behavioral performance

Collaborators (13)

Marina Rubio

bruno lefebvre

Yannick Vermeiren

Morvane Colin

Victoria Gómez Murcia

Stephanie Schorge

Kevin Richetin

Julien Puyal

Devrim Kilinc

Corrado Calì

Nicolas Toni

Paola Bezzi

Sylvain Perriot

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