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Nigel Mongan

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Professor of Oncology

University of Nottingham

United Kingdom

Research Interests

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About

Professor Nigel Mongan is a Professor of Oncology at the University of Nottingham, United Kingdom. His research focuses on various aspects of cancer biology, including outcome prediction in breast cancer, the molecular mechanisms of endometrial cancer, and comparative studies of osteosarcoma in humans and canines. He has also contributed to understanding the role of mesenchymal cells in cholangiocarcinoma and the implications of glutamine metabolism in breast cancer prognosis.

Recent Grants

Grant: Open

SAMBAI: Social, Ancestry, Molecular and Biological Analysis of Inequalities

Open Date: 2024-05-01

Close Date: 2029-04-01

Grant: Open

Epitranscriptomic mechanisms of treatment resistance in prostate caner

Open Date: 2023-02-01

Close Date: 2027-02-01

Grant: Close

Epitranscriptomic mechanisms of advanced prostate cancer

Open Date: 2023-01-01

Close Date: 2025-12-01

Grant: Close

Gene switches and treatment resistance in cancer

Open Date: 2022-10-01

Close Date: 2026-09-30

Grant: Close

Is the methyltransferase, ASH1L a therapeutic target for endocrine-related cancers?

Open Date: 2021-10-01

Close Date: 2025-09-30

Articles (45)

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Collaborators (26)

Simon Welham

Lecturer

University of Nottingham

UNITED KINGDOM

Nigel Mongan

Research Interests

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About

Recent Grants

Articles (45)

Identification and Characterisation of Canine Osteosarcoma Biomarkers and Therapeutic Targets

Modifying Epigenetic Landscapes to Restore Immune Therapeutic Responses in Triple Negative Breast Cancer

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Sub-stoichiometric 5-methoxyuridine modification enables tunable immune evasion and protein expression from synthetic mRNAs.

Loss of endothelial ZEB1 enhances neovascularisation during choroidal neovascularisation.

Ectopic expression of the transcriptional regulator and m6A writer complex member HIZ1 impacts development in Arabidopsis

Clinicopathological and functional evaluation of replication protein A in epithelial ovarian cancers: A target validation study.

Epigenetic Therapies in Endocrine-Related Cancers: Past Insights and Clinical Progress

Comparison of Differentially Expressed Genes in Human and Canine Osteosarcoma

Transcription Factor p73 Is a Predictor of Platinum Resistance and Promotes Aggressive Epithelial Ovarian Cancers

Outcome prediction of oestrogen receptor‐positive breast cancer based on a panel of oestrogen receptor‐regulated genes

Insulin-like Growth Factor 1 (IGF1) and Its Isoforms: Insights into the Mechanisms of Endometrial Cancer

Clinicopathological Significance of Transcription Factor p73 in Breast Cancers: Protein Expression and Transcriptomic Study

Functional and clinical significance of the RNA m6A methyltransferase complex in breast cancer

Comparative Digital Estrogen Receptor Alpha (ERα) Expression Analysis in Benign and Malignant Prostate Tissue of Men and Dogs.

Erratum to "Prediction of Response to Anti-HER2 Therapy Using A Multigene Assay" [Modern Pathology 38 (2025) 100713].

Investigation of ribociclib, abemaciclib and palbociclib resistance in ER+ breast cancer cells reveal potential therapeutic opportunities`.

The functional and therapeutic potential of epitranscriptomics in breast cancer.

Evaluation of human papillomavirus as a risk factor in prostate cancer pathogenesis.

Characterisation of HER2-Driven Morphometric Signature in Breast Cancer and Prediction of Risk of Recurrence.

Cardiotoxicity of breast cancer drug treatments.

Immunohistochemical Investigation into Protein Expression Patterns of FOXO4, IRF8 and LEF1 in Canine Osteosarcoma

Immune infiltration, aggressive pathology, and poor survival outcomes in RECQL helicase deficient breast cancers

The role of the ALKBH5 RNA demethylase in invasive breast cancer

Hydroxyacid Oxidase 1, a Glutamine Metabolism-Associated Protein, Predicts Poor Patient Outcome in Luminal Breast Cancer.

The role of mesenchymal cells in cholangiocarcinoma

Geometric characteristics of stromal collagen fibres in breast cancer using differential interference contrast microscopy.

Prognostic and Clinical Significance of the Proliferation Marker MCM7 in Breast Cancer.

The Conflicting Prognostic Role of the Stroma-Tumor Ratio in Breast Cancer Molecular Subtypes.

Epitranscriptomic mechanisms of androgen signalling and prostate cancer.

Alternative Splicing Events and Their Clinical Significance in Colorectal Cancer: Targeted Therapeutic Opportunities

Targeting DNA damage repair precision medicine strategies in cancer

The importance of m6A topology in chicken embryo mRNA: a precise mapping of m6A at the conserved chicken β-actin zipcode

Activated tissue resident memory T-cells (CD8+CD103+CD39+) uniquely predict survival in left sided “immune-hot” colorectal cancers

NDUFA4L2 reduces mitochondrial respiration resulting in defective lysosomal trafficking in clear cell renal cell carcinoma.

Characteristics and prognostic significance of polo‐like kinase‐1 (PLK1) expression in breast cancer

Encapsulated papillary carcinoma of the breast: does it have a native basement membrane?

The KDM5B and KDM1A lysine demethylases cooperate in regulating androgen receptor expression and signalling in prostate cancer.

Unravelling the clinicopathological and functional significance of replication protein A (RPA) heterotrimeric complex in breast cancers.

Expression, assessment and significance of Ki67 expression in breast cancer: an update.

Identification of MicroRNAs Associated with Histological Grade in Early-Stage Invasive Breast Cancer

Differential response of HER2-positive breast cancer to anti-HER2 therapy based on HER2 protein expression level.

Evaluation of tumour infiltrating lymphocytes in luminal breast cancer using artificial intelligence.

The Clinical and Biological Significance of Estrogen Receptor-Low Positive Breast Cancer.

Deciphering the Morphology of Tumor-Stromal Features in Invasive Breast Cancer Using Artificial Intelligence.

Collaborators (26)

Simon Welham

Srinivasan Madhusudan

Jennie Jeyapalan

Sheeba Irshad

Ryan M. Williams

Nathan Archer

Catrin Rutland

Mohsin Bilal

Cinzia Allegrucci

Jennifer Ashworth

Andrew Green

Rupert Fray

Thulo Molefi

Sven Rottenberg

KYONG HWA PARK

Judith Ramage

Madhusudhan Srinivasan

Naohiko Seki

Helen Miranda Knight

Tania Dottorini

Victoria James

Simone de Brot

Emad A Rakha

Andrew Benest

David Bates

Ali Fakroun

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