Nina Isoherranen

Professor and Chair

University of Washington

United States

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Professor Nina Isoherranen serves as the Chair at the University of Washington in the United States. Her research focuses on pharmacokinetic modeling, drug interactions, and the metabolism of small molecules, with recent publications highlighting advancements in proteomics and the effects of pregnancy on drug disposition. She is also involved in developing tools for visualizing and analyzing mass spectrometry data.

Articles (19)

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2025

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2022

Collaborators (8)

Michael L. Granda

University of Washington

UNITED STATES

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Rheem Totah

UNITED STATES

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Klarissa Jackson

Assistant Professor

University of North Carolina at Chapel Hill

UNITED STATES

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Robert Moritz

Institute for Systems Biology

UNITED STATES

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Matthew Bush

Associate Professor

University of Washington

UNITED STATES

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Mary F. Hebert

UNITED STATES

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Jessica Beers

Assistant Professor

University of Washington

UNITED STATES

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Lindsay Czuba

Assistant Professor

University of Kentucky

UNITED STATES

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Nina Isoherranen

Research Interests

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About

Articles (19)

Limelight: An Open, Web-Based Tool for Visualizing, Sharing, and Analyzing Mass Spectrometry Data from DDA Pipelines

Development and Validation of a Novel LC-MS/MS-Based Proteomics Method for Quantitation of Retinol Binding Protein 4 (RBP4) and Transthyretin (TTR)

Drug Interaction PBPK Modeling: Review of the Literature Exposes the Need for Increased Verification of Model Inputs and Outputs as Part of Credibility Assessment

Drugs Form Ternary Complexes with Human Liver Fatty Acid Binding Protein 1 (FABP1) and FABP1 Binding Alters Drug Metabolism

The ADME characteristics of siRNA therapeutics and the opportunity to predict disposition in pregnant women.

LX-2 Stellate Cells Are a Model System for Investigating the Regulation of Hepatic Vitamin A Metabolism and Respond to Tumor Necrosis Factorαand Interleukin 1β

Physiologically Based Pharmacokinetic (PBPK) Modeling of small molecules: How Much Progress Have We Made?

Predicting complex kidney drug handling using a physiologically‐based pharmacokinetic model informed by biomarker‐estimated secretory clearance and blood flow

Application of a physiologically based pharmacokinetic model to predict isoniazid disposition during pregnancy

The Utility of Mixed-Effects Models in the Evaluation of Complex Genomic Traits In Vitro

CYP2D6 activity is correlated with changes in plasma concentrations of taurocholic acid during pregnancy and postpartum in CYP2D6 extensive metabolizers

Impact of Intracellular Lipid Binding Proteins on Endogenous and Xenobiotic Ligand Metabolism and Disposition

Cytosolic Enzymes Generate Cannabinoid Metabolites 7-Carboxycannabidiol and 11-Nor-9-carboxytetrahydrocannabinol

The Effects of Pregnancy on Amino Acid Levels and Nitrogen Disposition

Effects of Pregnancy on Plasma Sphingolipids Using a Metabolomic and Quantitative Analysis Approach

Objective Identification of Cannabis Use Levels in Clinical Populations Is Critical for Detecting Pharmacological Outcomes

Isotretinoin and its Metabolites Alter mRNA of Multiple Enzyme and Transporter Genes In Vitro, but Downregulation of Organic Anion Transporting Polypeptide Does Not Translate to the Clinic

CRABPs Alter all-trans-Retinoic Acid Metabolism by CYP26A1 via Protein-Protein Interactions

Plasma Retinoid Concentrations Are Altered in Pregnant Women

Collaborators (8)

Michael L. Granda

Rheem Totah

Klarissa Jackson

Robert Moritz

Matthew Bush

Mary F. Hebert

Jessica Beers

Lindsay Czuba

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