Olaf Klingbeil

Head - Laboratory for Functional Genomics and Gene Regulation (VIB-KU Leuven)

KU Leuven

Belgium

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About

Olaf Klingbeil is the Head of the Laboratory for Functional Genomics and Gene Regulation at KU Leuven in Belgium. His research focuses on the molecular mechanisms underlying pancreatic cancer, acute myeloid leukemia, and glioblastoma, as well as the roles of transcription factors and epigenetic regulation in cancer cell identity and growth. Recent publications include studies on the impact of mucus production on pancreatic ductal adenocarcinoma and the exploration of transcriptional dependencies in acute myeloid leukemia.

Articles (10)

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2024

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2024

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2023

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2022

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2022

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2022

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2021

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2021

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2021

Year:

2020

Collaborators (3)

Emily Hodges

Vanderbilt University

UNITED STATES

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Benjamin Spike

University of Utah

UNITED STATES

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Xueqin (Sherine) Sun

Assistant Professor

Sanford Burnham Prebys Medical Discovery Institute

UNITED STATES

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Olaf Klingbeil

Research Interests

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Articles (10)

A mucus production programme promotes classical pancreatic ductal adenocarcinoma.

IκBζ is a dual-use coactivator of NF-κB and POU transcription factors.

BRD8 maintains glioblastoma by epigenetic reprogramming of the p53 network

FoxA1 and FoxA2 control growth and cellular identity in NKX2-1-positive lung adenocarcinoma.

Comparative optimization of combinatorial CRISPR screens.

SCP4-STK35/PDIK1L complex is a dual phospho-catalytic signaling dependency in acute myeloid leukemia.

Transcriptional silencing of ALDH2 confers a dependency on Fanconi anemia proteins in acute myeloid leukemia.

SLC5A3-Dependent Myo-inositol Auxotrophy in Acute Myeloid Leukemia.

The human origin recognition complex is essential for pre-RC assembly, mitosis, and maintenance of nuclear structure.

Squamous trans-differentiation of pancreatic cancer cells promotes stromal inflammation.

Collaborators (3)

Emily Hodges

Benjamin Spike

Xueqin (Sherine) Sun

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