Olli Kärkkäinen
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Recent Grants
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Role of gut microbiota associated metabolites in alcohol-associated liver disease
Open Date: 2021-01-01
Close Date: 2022-01-01
Grant: Close
Using metabolic phenotypes to guide personalized drug treatment of alcohol use disorder
Open Date: 2017-01-01
Close Date: 2018-12-01
Grant: Close
KuBiCo metabolomics
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Articles (11)
Smoking during pregnancy is one of the leading causes for adverse pregnancy outcomes. We studied parental smoking both before and during pregnancy in a retrospective cohort of 21 472 singleton pregnancies. Although most smoking women (74%) ceased tobacco use, there was possible gestational exposure to maternal cigarette smoking in every fifth pregnancy. Continued smoking throughout pregnancy was more prevalent in the partners (22%) than in the pregnant women (7%). The smoking behaviour of the women, especially the number of cigarettes smoked per day (CPD), before and in early pregnancy predicted the continuation of smoking throughout the pregnancy and could be used in identifying high risk groups. In addition, their partner's smoking habits both before and during pregnancy, were associated with the likelihood that the woman would continue to smoke during her pregnancy (r s ≈ 0.4). Furthermore, continued smoking of both parents were associated with decreased birth weight, head circumference and Apgar score, and increased duration of hospital stay and need for special care after birth. Consequently, addressing the lifestyles of both parents in the health care and maternity clinics could help in reducing maternal cigarette smoking during pregnancy and the adverse pregnancy outcomes associated with smoking.
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2024
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2023
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2022
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2022
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2022
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2022
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2022
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2022
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2021
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2021
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2021
Collaborators (13)
Ilona Luoma
Professor
University of Eastern Finland
Tiina Jääskeläinen
University of Helsinki
Hiroshi Tsugawa
Tokyo University of Agriculture and Technology
Mikael Niku
University of Helsinki
Eloise Kok
University of Tampere
Sophie Layé
University of Bordeaux
Aleksi Husso
University of Helsinki
Jaana Rysä
Professor
University of Eastern Finland
Miriam Cnop
Université libre de Bruxelles (ULB)
Soili Lehto
University of Helsinki
Kati Hanhineva
University of Eastern Finland
Laure B. Bindels
Assistant Professor
Université catholique de Louvain
Masanori Arita
Professor
National Institute of Genetics
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