Oscar Vargas-Rodriguez

Assistant Professor

University of Connecticut School of Medicine

United States

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Oscar Vargas-Rodriguez is an Assistant Professor at the University of Connecticut School of Medicine in the United States. His research primarily focuses on aminoacyl-tRNA synthetases and their roles in translation and mistranslation, as well as innovative approaches for suppressing pathogenic mutations. Recent publications highlight his work on engineered tRNAs and their applications in enhancing protein synthesis and understanding evolutionary mechanisms.

Articles (12)

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2025

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2025

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2024

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2024

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2024

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2024

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2023

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2022

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2022

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2022

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2021

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2020

Collaborators (8)

Dieter Soll

Professor

Yale University

UNITED STATES

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Sergey V Melnikov

Newcastle University

UNITED KINGDOM

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Henna Tyynismaa

University of Helsinki

FINLAND

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Jiqiang Ling

Associate Professor

University of Maryland at College Park

UNITED STATES

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Julie Maupin-Furlow

Professor

University of Florida

UNITED STATES

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Ziao Fu

Rockefeller University

UNITED STATES

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Takahito Mukai

Assitant Professor

Ryukoku University

JAPAN

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Eric Westhof

University of Strasbourg

FRANCE

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Oscar Vargas-Rodriguez

Research Interests

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About

Articles (12)

Mechanistic and evolutionary insights into a family of aminoacyl-tRNA deacylases that protects against canavanine toxicity

An engineered glutamic acid tRNA for efficient suppression of pathogenic nonsense mutations

AARS Online: A collaborative database on the structure, function, and evolution of the aminoacyl‐tRNA synthetases

Efficient suppression of premature termination codons with alanine by engineered chimeric pyrrolysine tRNAs

Coexisting bacterial aminoacyl‐tRNA synthetase paralogs exhibit distinct phylogenetic backgrounds and functional compatibility with Escherichia coli

The central role of transfer RNAs in mistranslation

Dual incorporation of non-canonical amino acids enables production of post-translationally modified selenoproteins

The tRNA discriminator base defines the mutual orthogonality of two distinct pyrrolysyl-tRNA synthetase/tRNAPyl pairs in the same organism

Uncovering translation roadblocks during the development of a synthetic tRNA

Diversification of aminoacyl-tRNA synthetase activities via genomic duplication

Bacterial translation machinery for deliberate mistranslation of the genetic code

Human trans-editing enzyme displays tRNA acceptor-stem specificity and relaxed amino acid selectivity

Collaborators (8)

Dieter Soll

Sergey V Melnikov

Henna Tyynismaa

Jiqiang Ling

Julie Maupin-Furlow

Ziao Fu

Takahito Mukai

Eric Westhof

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