Parthasarathy Seshacharyulu

Assistant professor

University of Nebraska Medical Center

United States

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Parthasarathy Seshacharyulu is an Assistant Professor at the College of Medicine, University of Nebraska Medical Center, USA. His research areas include cancer biology, specifically the mechanisms of drug resistance in prostate and pancreatic cancers, as well as the role of various signaling pathways in tumor progression and metastasis. His recent publications focus on the oncogenic potential of Gli3, transcriptional reprogramming in prostate cancer, and the impact of glycosylation on cancer stemness.

Articles (14)

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2025

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2025

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2024

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2023

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2022

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2021

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2021

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2020

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2020

Collaborators (10)

Benjamin A. Teply

University of Nebraska Medical Center

UNITED STATES

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Apar Kishor Ganti

Professor

University of Nebraska Medical Center

UNITED STATES

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Joseph Carmicheal

University of Nebraska Medical Center

UNITED STATES

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Ying Yan

Professor

University of Nebraska Medical Center

UNITED STATES

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Surinder K. Batra

University of Nebraska Medical Center

UNITED STATES

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Jawed Siddiqui

Assistant Professor

University of Nebraska Medical Center

UNITED STATES

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Sakthivel Muniyan

Assistant Professor

University of Nebraska Medical Center

UNITED STATES

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Jixin Dong

University of Nebraska Medical Center

UNITED STATES

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Satyanarayana Rachagani

University of Nebraska Medical Center

UNITED STATES

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Wade Junker

Assistant Professor (adjunct)

University of Nebraska Medical Center

UNITED STATES

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Parthasarathy Seshacharyulu

Research Interests

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Articles (14)

Oncogenic potential of truncated-Gli3 via the Gsk3β/Gli3/AR-V7 axis in castration-resistant prostate cancer

PAF1-mediated transcriptional reprogramming confers docetaxel resistance in advanced prostate cancer

Rac1 GTPase Regulates the βTrCP-Mediated Proteolysis of YAP Independently of the LATS1/2 Kinases

Understanding the function of Pax5 in development of docetaxel-resistant neuroendocrine-like prostate cancers

Targeting the EGFR signaling pathway in cancer therapy: What’s new in 2023?

Muc16 depletion diminishes KRAS-induced tumorigenesis and metastasis by altering tumor microenvironment factors in pancreatic ductal adenocarcinoma

GDF15 promotes prostate cancer bone metastasis and colonization through osteoblastic CCL2 and RANKL activation

Reduction in O-glycome induces differentially glycosylated CD44 to promote stemness and metastasis in pancreatic cancer

Disruption of FDPS/Rac1 axis radiosensitizes pancreatic ductal adenocarcinoma by attenuating DNA damage response and immunosuppressive signalling

ST6GalNAc‐I promotes lung cancer metastasis by altering MUC5AC sialylation

Amyloid Precursor-like Protein 2 Expression Increases during Pancreatic Cancer Development and Shortens the Survival of a Spontaneous Mouse Model of Pancreatic Cancer

Selective inhibition of stemness through EGFR/FOXA2/SOX9 axis reduces pancreatic cancer metastasis

Sildenafil Potentiates the Therapeutic Efficacy of Docetaxel in Advanced Prostate Cancer by Stimulating NO-cGMP Signaling

Acinar transformed ductal cells exhibit differential mucin expression in a tamoxifen-induced pancreatic ductal adenocarcinoma mouse model

Collaborators (10)

Benjamin A. Teply

Apar Kishor Ganti

Joseph Carmicheal

Ying Yan

Surinder K. Batra

Jawed Siddiqui

Sakthivel Muniyan

Jixin Dong

Satyanarayana Rachagani

Wade Junker

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