Pascal Devant

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Gladstone Institutes

United States

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Leveraging natural genetic diversity to discover mechanisms of inflammatory caspase activity.

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Articles (10)

Year:

2025

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2024

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2024

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2024

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2023

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2023

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2023

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2022

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2022

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2021

Collaborators (4)

Frank Baas

Professor of Genome Diagnostics

Leiden University

NETHERLANDS

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Carla Schmidt

Professor in Biochemistry

Johannes Gutenberg Universität Mainz

GERMANY

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Jianbin Ruan

Assistant Professor

University of Connecticut Health Center

UNITED STATES

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Bowen Gu

Harvard University

UNITED STATES

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Pascal Devant

Research Interests

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Contact this professor

Recent Grants

Articles (10)

LPS binding caspase activation and recruitment domains (CARDs) are bipartite lipid binding modules

ROS-dependent S-palmitoylation activates cleaved and intact gasdermin D

Structural transitions enable interleukin-18 maturation and signaling

The palmitoylation of gasdermin D directs its membrane translocation and pore formation during pyroptosis

Structural insights into cytokine cleavage by inflammatory caspase-4

Molecular mechanisms of gasdermin D pore-forming activity

Gasdermin D pore-forming activity is redox-sensitive

Glycine inhibits NINJ1 membrane clustering to suppress plasma membrane rupture in cell death

Protocol to purify recombinant inflammatory caspases and assess their catalytic activity in vitro

Assembly defects of human tRNA splicing endonuclease contribute to impaired pre-tRNA processing in pontocerebellar hypoplasia

Collaborators (4)

Frank Baas

Carla Schmidt

Jianbin Ruan

Bowen Gu

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