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Patrice Nordmann

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University of Fribourg

Switzerland

Research Interests

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Professors in Switzerland Professors in Microbiology Microbiology professors in Switzerland

About

Patrice Nordmann is an Associate Professor at the University of Fribourg, Switzerland. His research focuses on antimicrobial resistance, particularly the detection and characterization of β-lactamase enzymes in various pathogens. Recent publications include studies on the genomic analysis of Escherichia coli ST410 and the rapid detection of β-lactamase activity. He is also involved in exploring the efficacy of novel β-lactamase inhibitors in combination therapies.

Recent Grants

Grant: Close

RapidResa Polymyxin Acinetobacter NP Test for rapid detection of polymyxin restistance in Acinetobacter baumannii

Open Date: 2021-05-01

Close Date: 2021-05-31

Grant: Close

Emerging antibiotic resistance in Gram-negative bacilli; deciphering acquired resistance mechanisms to ß-lactam/ ß-lactamase inhibitor combinations and to fosfomycin

Open Date: 2020-03-01

Close Date: 2023-02-28

Grant: Close

Rapid diagnostic tests for detection of antibiotic resistance in clinically-significant Gram-negative bacteria

Open Date: 2018-02-01

Close Date: 2021-04-30

Grant: Close

Rapid diagnostic immunology-based test for detection of polymyxin resistance

Open Date: 2018-01-01

Close Date: 2018-01-01

Grant: Close

Implementation of routine audit and feedback on the use of protected anti-Gram-negative antibiotics: a multicenter, randomized trial using segmented regression analysis of interrupted time series

Open Date: 2017-03-01

Close Date: 2021-03-31

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Collaborators (21)

Niels Pfennigwerth

Ruhr-Universität Bochum

GERMANY

Patrice Nordmann

Research Interests

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About

Recent Grants

Articles (35)

Mechanisms of cefiderocol resistance in carbapenem-resistant Acinetobacter baumannii: a Swiss 2023–2025 collection

Characterization of the intrinsic AmpC β-lactamase of Escherichia marmotae and its impact on decreased susceptibility to cefiderocol and resistance to broad-spectrum cephalosporins

Phenotypic and biochemical characterization of the class C β-lactamase, PAC-1

Hydrogen cyanide generation by Pseudomonas aeruginosa blunts the host innate immune response

Phenotypic and genotypic characterization of HMB-3, a metallo-beta-lactamase from Pseudomonas asiatica

Beneficial impact of acquired AmpC β-lactamases on bacterial fitness and pathogenicity: a new paradigm

In vivo emergence of cross-resistance to ceftazidime/avibactam and cefiderocol through selection of KPC variants in Klebsiella pneumoniae clinical isolates

In vitro selection of cefiderocol-resistant mutants in Acinetobacter baumannii harbouring the most common carbapenemase genes

Evaluation of in vitro synergy of cefepime/enmetazobactam combined with aztreonam against metallo-β-lactamase-producing Enterobacterales

Rapid ESBL-Carba Combo PN test for simultaneous detection of ESBL and carbapenemase activity in Enterobacterales

Metallo-β-lactamase–producing Enterobacterales: cyanide-containing efflux pump inhibitors as potential dual-activity inhibitors

Occurrence of ESBL and carbapenemase producers and polymyxin- and fosfomycin-resistant Enterobacterales among pets in a veterinary clinic, Egypt

PKPD modeling of the inoculum effect of combined ceftazidime/avibactam and colistin against KPC-3 Klebsiella pneumoniae isolate

Genomic analyses of Escherichia coli ST410 harbouring the blaOXA-181 carbapenemase gene from companion animals and humans in Switzerland

Detection of ESBL-producing Klebsiella oxytoca complex with VITEK 2 system and screening cutoffs for implementing confirmatory tests

Rapid detection of cefepime-taniborbactam susceptibility/resistance in Enterobacterales

The emerging concern of IMP variants being resistant to the only IMP-type metallo-β-lactamase inhibitor, xeruborbactam

Rapid detection of β-lactamase activity using the rapid Amp NP test

In-vitro activity of newly-developed β-lactamase inhibitors avibactam, relebactam and vaborbactam in combination with anti-pseudomonal β-lactam antibiotics against AmpC-overproducing clinical Pseudomonas aeruginosa isolates

Inhibitory activity of meso-dimercaptosuccinic acid against IMP metallo-β-lactamase variants in Pseudomonas aeruginosa

The NitroSpeed Taniborbactam NP test as a rapid test for detection of β-lactamase-mediated susceptibility to taniborbactam

Carbapenem resistance in a Klebsiella quasipneumoniae isolate resulting from production of CTX-M-33 and OmpK36 porin deficiency

Emergence of vancomycin-resistant Enterococcus faecium vanA ST612 with reduced daptomycin susceptibility, Switzerland, 2018 to 2024

Relative inhibitory activities of newly developed diazabicyclooctanes, boronic acid derivatives, and penicillin-based sulfone β-lactamase inhibitors against broad-spectrum AmpC β-lactamases

Evaluation of Phenotypic Tests to Detect Extended-Spectrum β-Lactamase (ESBL)-Producing Klebsiella oxytoca Complex Strains

Impact of Acquired Broad Spectrum β-Lactamases on Susceptibility to Novel Combinations Made of β-Lactams (Aztreonam, Cefepime, Meropenem, and Imipenem) and Novel β-Lactamase Inhibitors in Escherichia coli and Pseudomonas aeruginosa

Rapid Aztreonam/Avibactam NP test for detection of aztreonam/avibactam susceptibility/resistance in Enterobacterales

Rapid meropenem/vaborbactam NP test for detecting susceptibility/resistance in Enterobacterales

Impact of veterinary antibiotics on plasmid-encoded antibiotic resistance transfer

Plasmid-mediated fosfomycin resistance in Escherichia coli isolates of worldwide origin

A Selective Culture Medium for Screening Cefiderocol Resistance in Enterobacterales , Pseudomonas aeruginosa, and Acinetobacter baumannii

Impact of Minor Carbapenemases on Susceptibility to Novel β-Lactam/β-Lactamase Inhibitor Combinations and Cefiderocol in Enterobacterales

Emergence of OXA-484, an OXA-48–type beta-lactamase, in Switzerland

In vitro-obtained meropenem-vaborbactam resistance mechanisms among clinical Klebsiella pneumoniae carbapenemase-producing K. pneumoniae isolates

Emergence of Carbapenemase-Producing Hypervirulent Klebsiella pneumoniae in Switzerland

Collaborators (21)

Niels Pfennigwerth

Charlotte Michaux

A Kronenberg

Laurence Senn

Nicolas Grégoire

Peter Keller

Mustafa Sadek

Alexia Chauzy

Vincent Perreten

Matteo Boattini

Adrian Egli

Andrea Endimiani

Jean-Winoc DECOUSSER

Marta Aires-de-Sousa

Jacqueline Findlay

Jorge Larios

Christophe LE TERRIER

Otávio Hallal Ferreira Raro

Laurent Poirel

Sandrine Marchand

julien buyck

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