Patricia Melnyk

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Professor

Université de Lille

France

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About

Patricia Melnyk is a Professor at Université de Lille II in France. Her research focuses on the development of novel pharmacological agents, particularly in the areas of sigma-1 receptor agonists, adenosine receptor antagonists, and interventions in neurodegenerative disorders. Recent publications highlight her work on therapeutic compounds targeting amyloid processing and the intersection of key signaling pathways in disease progression.

Recent Grants

Grant: Close

DRUG_MUC4

Open Date: 2016-01-01

Close Date: 2019-01-01

Grant: Close

New Sigma-1 Ligands for the treatment of neurodegenerative diseases

Open Date: 2015-01-01

Close Date: 2016-01-01

Grant: Close

VIDALZ

Open Date: 2015-01-01

Close Date: 2020-01-01

Grant: Close

Mise au point des techniques d’évaluation de l’interaction YAP/TEAD, une cible intéressante dans le contrôle de l’équilibre dormance/activation des cellules tumorales

Open Date: 2014-01-01

Close Date: 2014-01-01

Grant: Close

New sigma-1 ligands for neurodegenerative diseases

Open Date: 2013-01-01

Close Date: 2014-01-01

Articles (13)

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2025

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2025

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2024

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2023

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2022

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2022

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2022

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2022

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2022

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2021

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2021

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2020

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2020

Collaborators (7)

Xavier Thuru

Université de Lille

FRANCE

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Martine PUGNIERE

INSERM

FRANCE

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David Montaigne

FRANCE

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Nicolas LEBEGUE

Professor

Université de Lille

FRANCE

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Philippe Cotelle

Université de Lille

FRANCE

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Jean-Marc Taymans

Associate Professor

Université de Lille

FRANCE

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Patrick Vermersch

Professor

Université de Lille

FRANCE

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Patricia Melnyk

Research Interests

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About

Recent Grants

Articles (13)

Discovery of Novel Benzamide-Based Sigma-1 Receptor Agonists with Enhanced Selectivity and Safety

Towards the design of ligands of the internal pocket TEADs C-terminal domain

Novel Quinazoline Derivatives as Highly Effective A2A Adenosine Receptor Antagonists

A Polyaminobiaryl-Based β-secretase Modulator Alleviates Cognitive Impairments, Amyloid Load, Astrogliosis, and Neuroinflammation in APPSwe/PSEN1ΔE9 Mice Model of Amyloid Pathology

A Phosphosite Mutant Approach on LRRK2 Links Phosphorylation and Dephosphorylation to Protective and Deleterious Markers, Respectively

Crosstalk between the Hippo Pathway and the Wnt Pathway in Huntington’s Disease and Other Neurodegenerative Disorders

Discovery of Compounds That Selectively Repress the Amyloidogenic Processing of the Amyloid Precursor Protein: Design, Synthesis and Pharmacological Evaluation of Diphenylpyrazoles

Safe and Efficient Sigma1 Ligand: A Potential Drug Candidate for Multiple Sclerosis

Progress with YAP/TAZ-TEAD inhibitors: a patent review (2018-present)

Discovery of a cryptic site at the interface 2 of TEAD – Towards a new family of YAP/TAZ-TEAD inhibitors

Design, Synthesis and Evaluation of a Series of 1,5‐Diaryl‐1,2,3‐triazole‐4‐carbohydrazones as Inhibitors of the YAP‐TAZ/TEAD Complex

Synthesis of a novel series of (Z)-3,5-disubstituted thiazolidine-2,4-diones as promising anti-breast cancer agents

Quinazoline and phthalazine derivatives as novel melatonin receptor ligands analogues of agomelatine

Collaborators (7)

Xavier Thuru

Martine PUGNIERE

David Montaigne

Nicolas LEBEGUE

Philippe Cotelle

Jean-Marc Taymans

Patrick Vermersch

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