Patrick McNutt

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Associate Professor

Wake Forest School of Medicine

United States

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Recent Grants

Grant: Close

Toxic Mechanisms of Vesicating Chemicals in the Eye

Open Date: 2022-08-01

Close Date: 2025-08-01

Grant: Close

Treatment of botulism with 3,4-diaminopyridine phosphate

Open Date: 2022-08-01

Close Date: 2024-09-01

Grant: Close

Molecular mechanisms of botulinum neurotoxin neutralization

Open Date: 2016-05-10

Close Date: 2021-04-30

Grant: Open

Novel therapeutic approaches to treatment of botulinum neurotoxin poisoning.

Open Date: 2011-04-01

Close Date: 2027-06-01

Articles (16)

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2024

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2022

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2022

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2021

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2021

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2021

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2020

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2020

Collaborators (4)

Konstantin Ichtchenko

Assistant Professor (Research) of Biochemistry and Molecular Pharmacology

NYU School of Medicine

UNITED STATES

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Charles Shoemaker

Professor

Cummings School of Veterinary Medicine at Tufts University

UNITED STATES

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Elliot Glotfelty

Karolinska Institutet

SWEDEN

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Ryan Hanson

South Dakota State University

UNITED STATES

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Patrick McNutt

Research Interests

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Recent Grants

Articles (16)

The Degradation of Botulinum Neurotoxin Light Chains Using PROTACs

A comparative analysis of RNA-Seq and NanoString technologies in deciphering viral infection response in upper airway lung organoids.

Analysis of gene expression dynamics and differential expression in viral infections using generalized linear models and quasi-likelihood methods.

Aminopyridines Restore Ventilation and Reverse Respiratory Acidosis at Late Stages of Botulism in Mice

Treatment of Sulfur Mustard Corneal Injury by Augmenting the DNA Damage Response (DDR): A Novel Approach

Insights into optimizing exosome therapies for acute skin wound healing and other tissue repair.

Neuromuscular recovery from botulism involves multiple forms of compensatory plasticity

Therapeutic Benefits of Stem Cells and Exosomes for Sulfur-Mustard-Induced Tissue Damage

Progress towards a standardized model of ocular sulfur mustard injury for therapeutic testing

Antidotal treatment of botulism in rats by continuous infusion with 3,4-diaminopyridine

Urine-Derived Stem Cells for Epithelial Tissues Reconstruction and Wound Healing

Editorial: Venoms, Animal and Microbial Toxins

Dose-dependent emergence of acute and recurrent corneal lesions in sulfur mustard-exposed rabbit eyes

Neuronal delivery of antibodies has therapeutic effects in animal models of botulism

Functional basis for dose-dependent antagonism of rat and rabbit neuromuscular transmission by the bis-pyridinium oxime MMB4

Special Delivery: Potential Mechanisms of Botulinum Neurotoxin Uptake and Trafficking within Motor Nerve Terminals

Collaborators (4)

Konstantin Ichtchenko

Charles Shoemaker

Elliot Glotfelty

Ryan Hanson

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