Patrick O'Farrell

Professor

UCSF

United States

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Professor Patrick O'Farrell is a distinguished faculty member at UCSF, specializing in mitochondrial genetics and transcriptional regulation. His recent research articles delve into the impact of selfish mutations on mtDNA integrity, as well as the mechanisms linking pioneer factor activity to transcriptional bursts. Additionally, he explores the dynamics of mitochondrial genome stability and zygotic gene expression during early embryonic development in Drosophila.

Articles (5)

Year:

2025

Year:

2023

Year:

2022

Year:

2022

Year:

2020

Collaborators (1)

zev gartner

Professor

University of California, San Francisco

UNITED STATES

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Patrick O'Farrell

Research Interests

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Contact this professor

About

Articles (5)

Selfish mutations promote age-associated erosion of mtDNA integrity in mammals

Stepwise modifications of transcriptional hubs link pioneer factor activity to a burst of transcription

Mitigation of age-dependent accumulation of defective mitochondrial genomes

Temporal control of late replication and coordination of origin firing by self-stabilizing Rif1-PP1 hubs in Drosophila

Interphase-arrested Drosophila embryos activate zygotic gene expression and initiate mid-blastula transition events at a low nuclear-cytoplasmic ratio

Collaborators (1)

zev gartner

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