Patrick Rothwell

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Assistant Professor

University of Minnesota

United States

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About

Patrick Rothwell is an Assistant Professor at the University of Minnesota, USA. His research primarily focuses on neurology and decision-making, with recently published articles exploring the interactions between dopamine regulation, opioid signaling, and synaptic plasticity. He investigates sex differences in morphine sensitivity and the role of neuropeptide Y interneurons in the nucleus accumbens, contributing to the understanding of pain perception and behavioral adaptations to chronic opioid exposure.

Recent Grants

Grant: Close

Minnesota Inclusive Neuroscience Development Scholars (MINDS) doctoral readiness program

Open Date: 2022-09-15

Close Date: 2026-07-31

Grant: Open

Identification of small molecules that regulate endogenous opioid signaling by inhibiting angiotensin converting enzyme

Open Date: 2022-09-01

Close Date: 2027-07-31

Grant: Close

Domain-specific inhibition of angiotensin-converting enzyme as a therapeutic strategy for opioid use disorders

Open Date: 2022-07-01

Close Date: 2025-06-30

Grant: Close

Dysfunctional State Representations in Psychosis: From Neurophysiology to Neuroplasticity-based Treatment

Open Date: 2020-04-01

Close Date: 2025-03-31

Grant: Close

Unique Function and Degradation of an Exotic Endogenous Opioid Peptide

Open Date: 2020-04-01

Close Date: 2022-03-31

Articles (12)

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2025

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2024

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2024

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2024

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2023

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2022

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2022

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2022

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2021

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2020

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2020

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2020

Collaborators (4)

Ying Zhang

University of Minnesota

UNITED STATES

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Mohammed Mashal

Professionals-in-Training, Professional School Fellow

University of Minnesota

UNITED STATES

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Paulo Kofuji

Associate Professor

University of Minnesota

UNITED STATES

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Eduardo D. Martín

Instituto de Neurobiología Ramón y Cajal

SPAIN

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Patrick Rothwell

Research Interests

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Recent Grants

Articles (12)

Individual differences in decision-making shape how mesolimbic dopamine regulates choice confidence and change-of-mind

Sex differences in morphine sensitivity of neuroligin-3 knockout mice

Current understanding of the link between angiotensin-converting enzyme and pain perception.

Modulation of endogenous opioid signaling by inhibitors of puromycin-sensitive aminopeptidase.

Neuroligin‐3 in dopaminergic circuits promotes behavioural and neurobiological adaptations to chronic morphine exposure

Differential Patterns of Synaptic Plasticity in the Nucleus Accumbens Caused by Continuous and Interrupted Morphine Exposure.

Characterization and mu opioid receptor sensitivity of neuropeptide Y interneurons in the mouse nucleus accumbens

Angiotensin-converting enzyme gates brain circuit–specific plasticity via an endogenous opioid

μ-Opioid Receptor (Oprm1) Copy Number Influences Nucleus Accumbens Microcircuitry and Reciprocal Social Behaviors

Dopamine-Evoked Synaptic Regulation in the Nucleus Accumbens Requires Astrocyte Activity

Effect of Aggressive Experience in Female Syrian Hamsters on Glutamate Receptor Expression in the Nucleus Accumbens.

Interruption of continuous opioid exposure exacerbates drug-evoked adaptations in the mesolimbic dopamine system

Collaborators (4)

Ying Zhang

Mohammed Mashal

Paulo Kofuji

Eduardo D. Martín

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