Paulo Rodriguez

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Senior Member-Professor

H Lee Moffitt Cancer Center and Research Institute

United States

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Paulo Rodriguez is a Senior Member-Professor at the H Lee Moffitt Cancer Center and Research Institute in the United States. His research areas encompass targeted activation of Notch signaling, anticancer immunity, and cellular responses within the tumor microenvironment. Recently published articles include studies on T-cell mitochondrial dysfunction, immunogenic cell death in melanoma, and the immunosuppressive activities of macrophages in glioblastoma.

Recent Grants

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Bile acids restrict functional reprogramming of myeloid-derived suppressor cells in tumor beds

Open Date: 2021-09-15

Close Date: 2026-08-31

Grant: Close

Identifying Metabolic Vulnerabilities in Lung Cancer

Open Date: 2021-06-25

Close Date: 2026-05-31

Grant: Close

Functional reprogramming of tumor-MDSC through antibody-based therapies targeting Notch ligands

Open Date: 2019-06-06

Close Date: 2024-05-31

Grant: Close

ER stress blunts development of tissue resident memory T cells and restricts efficacy of T cell immunotherapy in ovarian carcinoma

Open Date: 2019-02-01

Close Date: 2020-01-31

Grant: Close

Mentoring Translational Researchers in Louisiana

Open Date: 2015-07-01

Close Date: 2020-06-30

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UNITED STATES

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Danh Tran

University of Washington

UNITED STATES

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Martin Kaczocha

Associate Professor

Stony Brook University Health Sciences Center School of Medicine

UNITED STATES

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David Munn

Augusta University

UNITED STATES

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Paulo Rodriguez

Research Interests

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About

Recent Grants

Articles (29)

Engineering synthetic agonists for targeted activation of Notch signaling

Endoplasmic reticulum stress responses in anticancer immunity

Blocking Nitrosylation Induces Immunogenic Cell Death by Sensitizing NRAS-Mutant Melanoma to MEK Inhibitors.

Functional reprogramming of neutrophils within the brain tumor microenvironment by hypoxia-driven histone lactylation.

Mitigating T-Cell Mitochondrial Dysfunction in CLL to Augment CAR T-Cell Therapy: Evaluation in an Immunocompetent Model.

Glucose-driven histone lactylation promotes the immunosuppressive activity of monocyte-derived macrophages in glioblastoma.

Jagged2 targeting in lung cancer activates anti-tumor immunity via Notch-induced functional reprogramming of tumor-associated macrophages.

Introduction to the special issue: B cells in cancer immunosurveillance.

Baseline Serum Inflammatory Proteins Predict Poor CAR T Outcomes in Diffuse Large B-cell Lymphoma.

Transgelin 2 guards T cell lipid metabolism and antitumour function

Oncolytic immunotherapy with nivolumab in muscle-invasive bladder cancer: a phase 1b trial.

Pan-cancer γδ TCR analysis uncovers clonotype diversity and prognostic potential.

BatchFLEX: feature-level equalization of X-batch.

Relationships among Inflammatory Biomarkers and Self-Reported Treatment-Related Symptoms in Patients Treated with Chemotherapy for Gynecologic Cancer: A Controlled Comparison

Differential requirements for CD4+ T cells in the efficacy of the anti-PD-1+LAG-3 and anti-PD-1+CTLA-4 combinations in melanoma flank and brain metastasis models.

Targeting intracellular oncoproteins with dimeric IgA promotes expulsion from the cytoplasm and immune-mediated control of epithelial cancers.

Enniatin A inhibits the chaperone Hsp90 and unleashes the immune system against triple-negative breast cancer.

Relationships among Inflammatory Biomarkers and Objectively Assessed Physical Activity and Sleep during and after Chemotherapy for Gynecologic Malignancies.

PATH-SURVEYOR: pathway level survival enquiry for immuno-oncology and drug repurposing.

Ovarian cancer immunogenicity is governed by a narrow subset of progenitor tissue-resident memory T cells

TGF-β-mediated silencing of genomic organizer SATB1 promotes Tfh cell differentiation and formation of intra-tumoral tertiary lymphoid structures

Tumor-directed dysregulation of erythroid progenitors drives immunosuppressive myeloid cells.

Carbon monoxide activates PERK-regulated autophagy to induce immunometabolic reprogramming and boost anti-tumor T cell function.

Single cell characterization of the cellular landscape of acral melanoma identifies novel targets for immunotherapy.

Increased inflammatory low-density neutrophils in severe obesity and effect of bariatric surgery: Results from case-control and prospective cohort studies.

Genomic and single-cell landscape reveals novel drivers and therapeutic vulnerabilities of transformed cutaneous T-cell lymphoma.

A preclinical model of patient-derived cerebrospinal fluid circulating tumor cells for experimental therapeutics in leptomeningeal disease from melanoma.

DRPPM-EASY: A Web-Based Framework for Integrative Analysis of Multi-Omics Cancer Datasets

Identification of Immunogenic MHC Class II Human HER3 Peptides that Mediate Anti-HER3 CD4 Th1 Responses and Potential Use as a Cancer Vaccine

Collaborators (14)

Maria Dulfary Sanchez-Pino

Brent Small

Hailey Bulls

Aik Choon Tan

Danielle Tometich

Danh Tran

Martin Kaczocha

David Munn

Roger Li

Timothy Shaw

Anna Vähärautio

Matias Marin Falco

william richardson

Kyle Payne

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