Pawel Swietach

University of Oxford

United Kingdom

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Articles (16)

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2024

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2024

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2022

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2022

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2022

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2022

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2022

Collaborators (8)

Slawomir Blonski

Institute of Fundamental Technological Research

POLAND

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Matthew Merritt

Associate Professor

University of Florida

UNITED STATES

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Walter Bodmer

Laboratory Head

University of Oxford

UNITED KINGDOM

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Nicholas Crump

Imperial College London

UNITED KINGDOM

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Damian Tyler

University of Oxford

UNITED KINGDOM

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Ebbe Boedtkjer

Aarhus University

DENMARK

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Andrew Trafford

The University of Manchester

UNITED KINGDOM

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Yu Jin Chung

King’s College London

UNITED KINGDOM

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Pawel Swietach

Research Interests

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Articles (16)

Innovating cancer drug discovery with refined phenotypic screens

Protocol for separating cancer cell subpopulations by metabolic activity using flow cytometry

What can we learn about acid-base transporters in cancer from studying somatic mutations in their genes?

Phenotypic screen of sixty-eight colorectal cancer cell lines identifies CEACAM6 and CEACAM5 as markers of acid resistance

Dynamic IL-6R/STAT3 signaling leads to heterogeneity of metabolic phenotype in pancreatic ductal adenocarcinoma cells

Acid-adapted cancer cells alkalinize their cytoplasm by degrading the acid-loading membrane transporter anion exchanger 2, SLC4A2

Permeability and driving force: why is difficult to control glycolytic flux by blocking lactate transporters?

How protons pave the way to aggressive cancers

Lipogenesis mediated by OGR1 regulates metabolic adaptation to acid stress in cancer cells via autophagy.

Acidic environments trigger intracellular H+-sensing FAK proteins to re-balance sarcolemmal acid-base transporters and auto-regulate cardiomyocyte pH.

Autoregulation of H+/lactate efflux prevents monocarboxylate transport (MCT) inhibitors from reducing glycolytic lactic acid production

Solute exchange through gap junctions lessens the adverse effects of inactivating mutations in metabolite-handling genes

Metabolic reprogramming under hypoxic storage preserves faster oxygen unloading from stored red blood cells.

Proton export upregulates aerobic glycolysis.

Channelling protons out of the heart

Alkaline nucleoplasm facilitates contractile gene expression in the mammalian heart.

Collaborators (8)

Slawomir Blonski

Matthew Merritt

Walter Bodmer

Nicholas Crump

Damian Tyler

Ebbe Boedtkjer

Andrew Trafford

Yu Jin Chung

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