peter butler

Professor

David Geffen School of Medicine at UCLA

United States

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Professor Peter Butler is a faculty member at the David Geffen School of Medicine at UCLA, USA. His research primarily focuses on diabetes, including the mechanisms of β-cell proteotoxicity, cholesterol homeostasis, and the roles of insulin and glucagon in metabolic responses. His recent articles highlight advancements in understanding type 1 and type 2 diabetes through innovative approaches such as live-cell imaging and stem cell-derived islet transplantation.

Articles (10)

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2024

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2023

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2022

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2021

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2021

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2021

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2021

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2020

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2020

Year:

2020

Collaborators (2)

Stephen D. Carter

University of Glasgow

UNITED KINGDOM

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Tatyana Gurlo

Adjunct Professor

UCLA Health

UNITED STATES

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peter butler

Research Interests

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Articles (10)

Dysregulation of cholesterol homeostasis is an early signal of β-cell proteotoxicity characteristic of type 2 diabetes

Efficacy of IAPP suppression in mouse and human islets by GLP-1 analogue conjugated antisense oligonucleotide.

Reversing type 1 diabetes with stem cell-derived islets: a step closer to the dream?

IAPP-induced beta cell stress recapitulates the islet transcriptome in type 2 diabetes.

The β-cell glucose toxicity hypothesis: Attractive but difficult to prove.

Live-cell imaging of glucose-induced metabolic coupling of β and α cell metabolism in health and type 2 diabetes.

Supplying Insulin while Evading Immunity.

Visualizing insulin vesicle neighborhoods in β cells by cryo-electron tomography.

Pancreatic alpha-cell mass across adult human lifespan.

Activation of the HIF1α/PFKFB3 stress response pathway in beta cells in type 1 diabetes

Collaborators (2)

Stephen D. Carter

Tatyana Gurlo

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