Philip Kiser

Associate Professor

University of California, Irvine

United States

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Dr. Philip Kiser is an Associate Professor at the University of California Irvine, United States. His research focuses on visual cycle modulation, the molecular mechanisms of retinal photoreceptors, and the enzymatic processes involving carotenoid oxygenases and isomerases. He has published several recent articles exploring advances in the therapeutic applications of RPE65 inhibitors and the dynamics of arrestin proteins in relation to vision.

Articles (17)

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2025

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2024

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2023

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2023

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2023

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2023

Collaborators (5)

Sanae Imanishi

Assistant Research Professor of Ophthalmology

Indiana State University

UNITED STATES

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Els Pardon

Vrije Universiteit Brussel

BELGIUM

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Jan Steyaert

Vrije Universiteit Brussel

BELGIUM

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Peter Calvert

Professor

SUNY Upstate Medical University

UNITED STATES

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Vladimir Kefalov

Professor

University of California, Irvine

UNITED STATES

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Philip Kiser

Research Interests

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About

Articles (17)

Rationally Designed, Short-Acting RPE65 Inhibitors for Visual Cycle-Associated Retinopathies

The molecular mechanisms of visual chromophore release from cellular retinaldehyde-binding protein

Advances and therapeutic opportunities in visual cycle modulation

Spectroscopy and crystallography define carotenoid oxygenases as a new subclass of mononuclear non-heme FeII enzymes

Insights into the Activation and Self-Association of Arrestin‑1

Safer and efficient base editing and prime editing via ribonucleoproteins delivered through optimized lipid-nanoparticle formulations

Restoring retinal polyunsaturated fatty acid balance and retina function by targeting ceramide in AdipoR1-deficient mice

Double-duty isomerases: a case study of isomerization-coupled enzymatic catalysis

Carotenoid cleavage enzymes evolved convergently to generate the visual chromophore.

Dominant role for pigment epithelial CRALBP in supplying visual chromophore to photoreceptors.

Retinylidene chromophore hydrolysis from mammalian visual and non-visual opsins.

A combination treatment based on drug repurposing demonstrates mutation-agnostic efficacy in pre-clinical retinopathy models

Mechanisms of amphibian arrestin 1 self-association and dynamic distribution in retinal photoreceptors

Structural basis for the allosteric modulation of rhodopsin by nanobody binding to its extracellular domain

Rapid RGR-dependent visual pigment recycling is mediated by the RPE and specialized Müller glia.

Tuning the Metabolic Stability of Visual Cycle Modulators through Modification of an RPE65 Recognition Motif.

Stress resilience-enhancing drugs preserve tissue structure and function in degenerating retina via phosphodiesterase inhibition

Collaborators (5)

Sanae Imanishi

Els Pardon

Jan Steyaert

Peter Calvert

Vladimir Kefalov

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