Philipp Zickler

Background and purpose Acute stroke treatment and secondary prevention have tremendously improved functional outcomes after stroke. However, this does not always imply a likewise improvement in health‐related quality of life (HRQoL). Knowledge on factors influencing HRQoL after stroke is still scarce, especially regarding social aspects like the level of education and the presence of migration background. Methods In the present stroke cohort study, participants were interviewed during their hospital stay and completed a postal questionnaire at 3 and 12 months post stroke. Functional outcomes were assessed by the modified Rankin Scale and HRQoL by evaluating the detailed Stroke Impact Scale (SIS). Logistic regression models were used to determine associations between education, migration background and quality of life end‐points. Results A total of 945 (mean age 69 years; 56% male) stroke patients were enrolled. After adjusting for confounders, a lower educational level was associated with worse functional outcomes in the SIS domain ‘strength’ (odds ratio 2.67, 95% confidence interval 1.6–4.4, p < 0.001). Migration background was associated with worse outcomes in the SIS domain ‘emotion’ ( p = 0.007, odds ratio 1.71, 95% confidence interval 1.2–2.5). Additionally, for female patients worse HRQoL outcomes were found in multiple other SIS domains. Conclusions Migration background and a lower educational level were significantly associated with lower long‐term HRQoL after stroke. These aspects should be considered in targeted rehabilitation programmes and follow‐up support of stroke patients.