Philippe Sarret

Full professor

Université de Sherbrooke

Canada

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Philippe Sarret is a Full Professor at Université de Sherbrooke, Canada. His research focuses on opioid analgesics, neurotensin receptor type 2, and the metabolic functions associated with endocannabinoids. In recent articles, he has explored topics such as biased signaling in opioid pharmacology, peptide-based analgesics, and underlying mechanisms of pain hypersensitivity.

Articles (16)

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2025

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2021

Collaborators (7)

Émile Breault

Université de Sherbrooke

CANADA

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Sára Ferková

Lecturer

Bishop's University

CANADA

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Taha Azad

Ottawa Hospital Research Institute

CANADA

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Pierre-Luc Boudreault

Professor

Université de Sherbrooke

CANADA

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Élie Besserer-Offroy

Adjunct Professor

Université de Sherbrooke

CANADA

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Mannix Auger-Messier

Full Professor

Université de Sherbrooke

CANADA

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Robin Van Den Hauwe

Vrije Universiteit Brussel

BELGIUM

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Philippe Sarret

Research Interests

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About

Articles (16)

Opioid Analgesics: Rise and Fall of Ligand Biased Signaling and Future Perspectives in the Quest for the Holy Grail

A Metabolically Stable Apelin-13 Analog Acting as a Potent ITo Potassium Current Blocker with Potential Benefits for Brugada Syndrome

Plasma Endocannabinoids Are Independently Associated With the Metabolic Function of White Adipose Tissue

Development of Macrocyclic Neurotensin Receptor Type 2 (NTS2) Opioid‐Free Analgesics

Development of Macrocyclic Neurotensin Receptor Type 2 (NTS2) Opioid‐Free Analgesics

Opening the amino acid toolbox for peptide‐based NTS2‐selective ligands as promising lead compounds for pain management

Comparative Analysis of Cyclization Techniques in Stapled Peptides: Structural Insights into Protein–Protein Interactions in a SARS-CoV-2 Spike RBD/hACE2 Model System

Size-Reduced Macrocyclic Analogues of [Pyr<sup>1</sup>]-apelin-13 Showing Negative Gα<sub>12</sub>Bias Still Produce Prolonged Cardiac Effects

G alpha i-biased apelin analog protects against isoproterenol-induced myocardial dysfunction in rats

Mechanistic insights into the role of the chemokine CCL2/CCR2 axis in dorsal root ganglia to peripheral inflammation and pain hypersensitivity

Optogenetic stimulation of glutamatergic neurons in the cuneiform nucleus controls locomotion in a mouse model of Parkinson’s disease

Modulation of the Passive Permeability of Semipeptidic Macrocycles: N- and C-Methylations Fine-Tune Conformation and Properties

Design, Structural Optimization, and Characterization of the First Selective Macrocyclic Neurotensin Receptor Type 2 Non-opioid Analgesic

Apelin-13 in septic shock: effective in supporting hemodynamics in sheep but compromised by enzymatic breakdown in patients

Constraining the Side Chain of C-Terminal Amino Acids in Apelin-13 Greatly Increases Affinity, Modulates Signaling, and Improves the Pharmacokinetic Profile

Elabela Protects Spontaneously Hypertensive Rats From Hypertension and Cardiorenal Dysfunctions Exacerbated by Dietary High-Salt Intake

Collaborators (7)

Émile Breault

Sára Ferková

Taha Azad

Pierre-Luc Boudreault

Élie Besserer-Offroy

Mannix Auger-Messier

Robin Van Den Hauwe

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