Pierre-Henri Gaillard
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Recent Grants
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Investigating how SLX4 impacts replication stress outcome and genome stability
Open Date: 2016-01-01
Close Date: 2020-01-01
Grant: Close
Controlling the Mus81-Eme1 endonuclease for genome stability : Interplay between phosphorylation of Eme1 and SUMO-binding
Open Date: 2013-10-01
Close Date: 2017-09-30
Grant: Close
Role of the tumour suppressor SLX4 during normal replication and under stress conditions with emphasis on interactions with PCNA, Ubiquitin and SUMO
Open Date: 2012-12-26
Close Date: 2016-12-26
Grant: Close
Comprehensive Biology: Exploiting the Yeast Genome
Open Date: 1996-09-30
Close Date: 2012-06-30
Articles (4)
Year:
2023
The tumour suppressor SLX4 plays multiple roles in the maintenance of genome stability, acting as a scaffold for structure-specific endonucleases and other DNA repair proteins. It directly interacts with the mismatch repair (MMR) protein MSH2 but the significance of this interaction remained unknown until recent findings showing that MutSβ (MSH2-MSH3) stimulates in vitro the SLX4-dependent Holliday junction resolvase activity. Here, we characterize the mode of interaction between SLX4 and MSH2, which relies on an MSH2-interacting peptide (SHIP box) that drives interaction of SLX4 with both MutSβ and MutSα (MSH2-MSH6). While we show that this MSH2 binding domain is dispensable for the well-established role of SLX4 in interstrand crosslink repair, we find that it mediates inhibition of MutSα-dependent MMR by SLX4, unravelling an unanticipated function of SLX4.
Year:
2022
Year:
2022
Year:
2021
Collaborators (1)
Peter McHugh
University of Oxford
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