R. Kenneth Marcus

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Clemson University

United States

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R. Kenneth Marcus is a Professor at Clemson University, USA. His research focuses on the analysis and isolation of extracellular vesicles, particularly from bovine milk and urine, utilizing advanced chromatographic techniques. He has contributed significantly to the study of uranium isotopics and isotopic ratio determinations using mass spectrometry. His work is instrumental in improving methodologies for the detection and analysis of complex biological samples.

Recent Grants

Grant: Close

Capillary Channeled Polymer Structures and Chemistries for High Throughput Measurement of Large Molecules

Open Date: 2016-09-01

Close Date: 2020-02-29

Grant: Close

Capillary-Channeled Polymer Fibers: Chemistries and Structures for Protein Separations and Analytics

Open Date: 2013-09-15

Close Date: 2017-06-30

Grant: Close

Capillary-Channeled Polymer (C-CP) Fiber Stationary Phases for High Speed and Preparative Protein Separation

Open Date: 2010-08-15

Close Date: 2013-11-30

Grant: Close

Glow Discharge Atomization/Excitation/Ionization Sources

Open Date: 1998-02-01

Close Date: 2001-07-31

Grant: Close

Enhanced Utility of Radio Frequency Glow Discharge Sources

Open Date: 1994-12-01

Close Date: 1997-11-30

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2022

Collaborators (1)

Viktoria Mueller

The James Hutton Institute

UNITED KINGDOM

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R. Kenneth Marcus

Research Interests

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About

Recent Grants

Articles (26)

Feasibility of closing the PFAS mass balance: exploring the potential of liquid sampling atmospheric pressure glow discharge (LS-APGD) with Orbitrap mass spectrometry for neutral PFAS

Round Robin Analysis of Uranium Isotopics on Cotton Swipes Measured Using Microextraction-Based Sampling Versus Conventional Bulk Analysis

Effects of packing density and adsorption conditions on extracellular vesicle dynamic binding capacities for capillary-channeled polymer (C-CP) fiber columns

Isolation of bovine milk–derived extracellular vesicles via a capillary-channeled polymer (C-CP) fiber stationary phase

Isolation of Urinary Extracellular Vesicles (EVs) via Hydrophobic Interaction Chromatography Using a Nylon‐6 Capillary‐Channeled Polymer (C‐CP) Fiber Column

Parametric optimization of the liquid sampling-atmospheric pressure glow discharge ionization source coupled to an Orbitrap mass spectrometer for neodymium isotope ratio determinations

Detection of Br and I as atomic anions using liquid sampling – atmospheric pressure glow discharge/Orbitrap mass spectrometry

Complete resolution across the neodymium/samarium isotopic envelope with a liquid sampling‐atmospheric pressure glow discharge — Orbitrap mass spectrometer

Isolation and quantification of human urinary exosomes using a Tween-20 elution solvent from polyester, capillary-channeled polymer fiber columns

In-line coupling of capillary-channeled polymer fiber columns with optical absorbance and multi-angle light scattering detection for the isolation and characterization of exosomes

In-line buffer exchange in the coupling of Protein A chromatography with weak cation exchange chromatography for the determination of charge variants of immunoglobulin G derived from chinese hamster ovary cell cultures

In-line HPLC-ICP-MS method for the rapid speciation and quantification of metal constituents in cell culture media

Initial demonstration of microplasma ionization/Orbitrap mass spectrometry for molecular screening of perfluorinated compounds

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Initial Characterization and Optimization of the Liquid Sampling-Atmospheric Pressure Glow Discharge Ionization Source Coupled to an Orbitrap Mass Spectrometer for the Determination of Plutonium

Coupling of the Liquid Sampling–Atmospheric Pressure Glow Discharge to Orbitrap Mass Analyzers for Uranium Isotope Ratio Analysis: Evolution of the Methodology and Implications to the Field

Preliminary investigation of an uncertainty budget for uranium isotope ratio analysis using a liquid sampling—atmospheric pressure glow discharge—orbitrap mass spectrometer system

Rapid isolation and quantification of extracellular vesicles from suspension‐adapted human embryonic kidney cells using capillary‐channeled polymer fiber spin‐down tips

Rapid metal speciation of cell culture media using reversed‐phase separations and inductively coupled plasma optical emission spectrometry

Direct, multielement determinations from cotton swipes via plate express microextraction coupled to an inductively coupled plasma mass spectrometer (μEx-ICP-MS)

Quantitative Recoveries of Exosomes and Monoclonal Antibodies from Chinese Hamster Ovary Cell Cultures by Use of a Single, Integrated Two-Dimensional Liquid Chromatography Method

Loading characteristics of streptavidin on polypropylene capillary channeled polymer fibers and capture performance towards biotinylated proteins

Comparative analysis of trilobal capillary‐channeled polymer fiber columns with superficially porous and monolithic phases toward reversed‐phase protein separations

Determination of the Loading Capacity and Recovery of Extracellular Vesicles Derived from Human Embryonic Kidney Cells and Urine Matrices on Capillary-Channeled Polymer (C-CP) Fiber Columns

Comparison of the separation of proteins of wide‐ranging molecular weight via trilobal polypropylene capillary‐channeled polymer fiber, commercial superficiously porous, and commercial size exclusion columns

Facile, generic capture and on-fiber differentiation of exosomes via confocal immunofluorescence microscopy using a capillary-channeled polymer fiber solid-phase extraction tip

Collaborators (1)

Viktoria Mueller

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