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Raphael Leman

Has grant

INSERM

France

Research Interests

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Professors in France Professors in Biostatistics Biostatistics professors in France

Recent Grants

Grant: Open

Résolution de la structure des transcrits pour le diagnostic moléculaire des prédispositions héréditaires aux cancers par séquençage de troisième génération

Open Date: 2024-12-01

Close Date: 2026-12-01

Grant: Close

HERO: HRD test for Ovarian cancER

Open Date: 2023-01-01

Close Date: 2026-01-01

Grant: Close

Identification de nouveaux transcrits des gènes de prédisposition aux cancers du sein et/ou de l’ovaire par l’analyse combinée des données de séquençage à haut débit de courts et longs fragments d’ARN

Open Date: 2017-01-01

Close Date: 2019-01-01

Articles (20)

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Collaborators (33)

Abderaouf Hamza

Assistant Lecturer

Université Paris Cité

FRANCE

Raphael Leman

Research Interests

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Recent Grants

Articles (20)

ESR1 Mutation in Endocrine Treatment-Naïve Endometrial Cancer: Prevalence, Characteristics, and Prognostic Implications, Results from the UTOLA Phase II GINECO Trial

EML4::RET, a novel transcript fusion in papillary thyroid cancer

Association between molecular classification and overall survival in patients with metastatic endometrial carcinoma: ancillary results of the UTOLA phase II GINECO trial

&lt;i&gt;PFMG2025&lt;/i&gt;-integrating genomic medicine into the national healthcare system in France.

The PENDOR study: establishment of a panel of patient-derived tumor organoids from endometrial cancer to assess efficacy of PARP inhibitors.

Maintenance olaparib after platinum-based chemotherapy for advanced/metastatic endometrial cancer: GINECO randomized phase IIb UTOLA trial

RNA-based diagnostic studies in genetics: Review and guidance from a multidisciplinary French network

Automated Scoring to Assess RAD51-Mediated Homologous Recombination in Ovarian Patient-Derived Tumor Organoids

NSD3::NUTM1 fusion evidenced on RNA sequencing in poorly differentiated thyroid cancer: a report of two cases

Decipher RNA isoform combinations from minigene splicing assays and massive parallel sequencing with MAGIC

Homologous recombination deficiency (HRD) tests for ovarian cancer: a multicenter French phase II study (HERO)

Bridging the Diagnostic Gap in Hereditary Cancers with Simple, Cost-Effective, High-Throughput RNA Splicing Analysis

Identification of a germline deep intronic PTEN-deletion leading to exonization through whole genome and targeted RNA sequencing

Radiosensitizing Effect of PARP Inhibition on Chondrosarcoma and Chondrocyte Cells Is Dependent on Radiation LET

Predicting the impact of rare variants on RNA splicing in CAGI6

The OVAREX study: Establishment of ex vivo ovarian cancer models to validate innovative therapies and to identify predictive biomarkers.

Fine mapping of RNA isoform diversity using an innovative targeted long-read RNA sequencing protocol with novel dedicated bioinformatics pipeline

1977P Efficacy of talazoparib and avelumab as a maintenance treatment in patients with advanced/metastatic urothelial carcinoma (mUC) whose disease did not progress after a first-line platinum-based chemotherapy (PBCT): The GETUG-TALASUR trial

41MO ESR1 mutation in untreated endometrial cancer: Prevalence, characteristics and prognostic implications from the UTOLA trial

Carboplatin in metastatic castration-resistant prostate cancer patients with molecular alterations of the DNA damage repair pathway: the PRO-CARBO phase II trial

Collaborators (33)

Abderaouf Hamza

Laetitia Gouas

Benjamin Fournier

Sylvie Jaillard

Pascaline Gaildrat

Louis-Bastien Weiswald

Agnes Bloch-Zupan

Jean Muller

Paul Kuentz

Richard Redon

Louise-Marie CHEVALIER

Caroline Rooryck

Alexandra Martins

Christine Bellanné-Chantelot

Martin Figeac

Eric Pasmant

isabelle ray coquard

Sarah Baer

Agathe Ricou

Matthieu Egloff

Sergey Nikolaev

Pierre Vande Perre

Hélène Cavé

Florence Petit

David N Church

Jenny Lord

Manuel Rodrigues

Catherine Chaussain

Antoine Italiano

Benoit You

Pierre‐Marie Morice

samuel VALABLE

Pierre Laurent-Puig

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<i>PFMG2025</i>-integrating genomic medicine into the national healthcare system in France.