Raul Padron

Professor

UMass Memorial Medical Center University Campus

United States

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Raul Padron is a Professor at UMass Memorial Medical Center University Campus in the United States. His research focuses on the structural and functional dynamics of myosin in striated muscles, with recent publications highlighting the implications of myosin mutations and interactions in cardiac and skeletal muscle function. He employs advanced techniques such as cryo-EM to explore mechanisms related to cardiomyopathy and muscle energetics.

Articles (10)

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2024

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2023

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2023

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2022

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2022

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2021

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2020

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2020

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2020

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2020

Collaborators (2)

Roger Craig

UNITED STATES

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Kyounghwan Lee

Assistant Professor

University of Massachusetts Boston

UNITED STATES

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Raul Padron

Research Interests

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Articles (10)

Dominant myosin storage myopathy mutations disrupt striated muscles in Drosophila and the myosin tail-tail interactome of human cardiac thick filaments.

Variants of the myosin interacting-heads motif

Cryo-EM structure of the human cardiac myosin filament

Interacting-heads motif explains the X-ray diffraction pattern of relaxed vertebrate skeletal muscle

Structural basis of the super- and hyper-relaxed states of myosin II

Relaxed tarantula skeletal muscle has two ATP energy-saving mechanisms

Cryo-EM structure of the inhibited (10S) form of myosin II

The myosin interacting-heads motif present in live tarantula muscle explains tetanic and posttetanic phosphorylation mechanisms

Myosin Sequestration Regulates Sarcomere Function, Cardiomyocyte Energetics, and Metabolism, Informing the Pathogenesis of Hypertrophic Cardiomyopathy

18O labeling on Ser45 but not on Ser35 supports the cooperative phosphorylation mechanism on tarantula thick filament activation

Collaborators (2)

Roger Craig

Kyounghwan Lee

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