Rebecca DuBois

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Professor

University of California, Santa Cruz

United States

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About

Rebecca DuBois is a Professor at the University of California Santa Cruz, USA. Her research focuses on vaccine development and the structural biology of viral interactions, as highlighted in her recent articles on topics such as immunogenicity of respiratory syncytial virus vaccines and antibody interactions with influenza hemagglutinin proteins. She has contributed significantly to understanding the antigenicity of various astroviruses and the structural basis of neutralizing antibodies.

Recent Grants

Grant: Close

Structure-guided design of a safe and effective Respiratory Syncytial Virus G protein immunogen

Open Date: 2019-09-01

Close Date: 2020-08-31

Grant: Close

Structural, mechanistic, and antigenic insights into the human astrovirus capsid

Open Date: 2019-02-20

Close Date: 2024-01-31

Grant: Close

Structural Requirements for Broadly Protecting Antibodies to the Respiratory Syncytial Virus G Protein

Open Date: 2017-12-05

Close Date: 2019-11-30

Grant: Close

Structural and mechanistic insights into antibody neutralization of human astrovirus

Open Date: 2017-09-01

Close Date: 2018-08-31

Grant: Close

Crystal structures and mechanism of disease of the astrovirus capsid protein

Open Date: 2013-07-24

Close Date: 2015-06-30

Articles (20)

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2021

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2020

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2020

Collaborators (4)

Ralph Tripp

Professor and Georgia Research Alliance Chair

University of Georgia

UNITED STATES

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Larry Anderson

Professor

Emory University

UNITED STATES

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Valerie Cortez

Fred Hutchinson Cancer Research Center

UNITED STATES

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Jarrod Mousa

Assistant Professor

University of Georgia

UNITED STATES

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Rebecca DuBois

Research Interests

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About

Recent Grants

Articles (20)

Assessing the structural boundaries of broadly reactive antibody interactions with diverse H3 influenza hemagglutinin proteins.

Restricting O-Linked Glycosylation of the Mucin-like Domains Enhances Immunogenicity and Protective Efficacy of a Respiratory Syncytial Virus G Glycoprotein Vaccine Antigen

Functional characterization of DPP4 and FcRn as receptor and coreceptor for classical human astroviruses in Caco-2 cells.

Layer-by-Layer Microparticle Vaccines Containing a S177Q Point Mutation in the Central Conserved Domain of the RSV G Protein Improves Immunogenicity.

Structures of respiratory syncytial virus G bound to broadly reactive antibodies provide insights into vaccine design.

Discovery of three novel neutralizing antibody epitopes on the human astrovirus capsid spike and mechanistic insights into virus neutralization.

Structure and antigenicity of the divergent human astrovirus VA1 capsid spike

Structural basis for the broad antigenicity of the computationally optimized influenza hemagglutinin X6.

Structure and Antigenicity of the Porcine Astrovirus 4 Capsid Spike

Mouse and human immune responses share neutralization epitopes of HAstV-VA1.

Immune Prophylaxis Targeting the Respiratory Syncytial Virus (RSV) G Protein

Structure and immunogenicity of the murine astrovirus capsid spike

Structure of the divergent human astrovirus MLB capsid spike

The Capsid Precursor Protein of Astrovirus VA1 Is Proteolytically Processed Intracellularly

Structure-Based Design and Antigenic Validation of Respiratory Syncytial Virus G Immunogens

Structures of Two Human Astrovirus Capsid/Neutralizing Antibody Complexes Reveal Distinct Epitopes and Inhibition of Virus Attachment to Cells

Human Astrovirus 1–8 Seroprevalence Evaluation in a United States Adult Population

Respiratory Syncytial Virus (RSV) G Protein Vaccines With Central Conserved Domain Mutations Induce CX3C-CX3CR1 Blocking Antibodies

Protein Disulfide Isomerase A4 Is Involved in Genome Uncoating during Human Astrovirus Cell Entry.

Conformational Flexibility in Respiratory Syncytial Virus G Neutralizing Epitopes

Collaborators (4)

Ralph Tripp

Larry Anderson

Valerie Cortez

Jarrod Mousa

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