Richard Longnecker

Northwestern University Feinberg School of Medicine

United States

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Articles (10)

Year:

2024

Year:

2024

Enveloped viruses enter cells by fusing their envelope with the host cell membrane. Herpes simplex virus 1 (HSV-1) entry requires the coordinated interaction of several viral glycoproteins, including gH/gL and gB. gH/gL and gB are essential for virus replication and both proteins are targets of neutralizing antibodies. gB fuses the membranes after being activated by gH/gL, but the details of how gH/gL activates gB are not known.

Year:

2023

Year:

2022

Year:

2021

Year:

2021

Year:

2021

Year:

2020

Year:

2020

Year:

2020

Collaborators (2)

Theodore Jardetzky

Professor

Stanford University School of Medicine

UNITED STATES

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Sarah A. Connolly

DePaul University

UNITED STATES

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Richard Longnecker

Research Interests

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Articles (10)

Leveraging biotin-based proximity labeling to identify cellular factors governing early alphaherpesvirus infection

Structures of Epstein-Barr virus and Kaposi’s sarcoma-associated herpesvirus virions reveal species-specific tegument and envelope features

Multiple Sites on Glycoprotein H (gH) Functionally Interact with the gB Fusion Protein to Promote Fusion during Herpes Simplex Virus (HSV) Entry

The Astrocyte Type I Interferon Response Is Essential for Protection against Herpes Simplex Encephalitis

The structural basis of herpesvirus entry

Herpes Simplex Virus Glycoprotein B Mutations Define Structural Sites in Domain I, the Membrane Proximal Region, and the Cytodomain That Regulate Entry

ASC-dependent inflammasomes contribute to immunopathology and mortality in herpes simplex encephalitis

Epstein-Barr Virus gH/gL and Kaposi’s Sarcoma-Associated Herpesvirus gH/gL Bind to Different Sites on EphA2 To Trigger Fusion

Herpesvirus Entry Mediator Binding Partners Mediate Immunopathogenesis of Ocular Herpes Simplex Virus 1 Infection

The Innate Immune Response to Herpes Simplex Virus 1 Infection Is Dampened in the Newborn Brain and Can Be Modulated by Exogenous Interferon Beta To Improve Survival

Collaborators (2)

Theodore Jardetzky

Sarah A. Connolly

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