Richard McCulloch

Professor of Molecular and Cellular Parasitology

University of Glasgow

United Kingdom

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Richard McCulloch is a Professor of Molecular and Cellular Parasitology at the University of Glasgow, UK. His research focuses on the molecular mechanisms of parasitic diseases, particularly in the context of Leishmania and Trypanosoma species. Recent publications explore topics such as DNA replication dynamics, genome stability, and gene expression regulation in trypanosomatid parasites.

Articles (13)

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2025

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2025

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2025

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2025

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2025

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2024

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2023

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2021

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2020

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UNITED KINGDOM

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Catarina de Almeida Marques

University of Glasgow

UNITED KINGDOM

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Professor Keith Matthews FRS FMedSci FRSE

Professor of Parasite Biology

University of Edinburgh

UNITED KINGDOM

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Gabriel Lamak Almeida Da Silva

University of Glasgow

UNITED KINGDOM

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Dario Beraldi

Head of Bioinformatics Core Facility

University of Glasgow

UNITED KINGDOM

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Richard McCulloch

Research Interests

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Articles (13)

Leishmania major chromosomes are replicated from a single high-efficiency locus supplemented by thousands of lower efficiency initiation events

TrAGEDy—trajectory alignment of gene expression dynamics

R-loops acted on by RNase H1 influence DNA replication timing and genome stability in Leishmania

Nanopore sequencing reveals that DNA replication compartmentalisation dictates genome stability and instability in Trypanosoma brucei

Do tissue-dwelling trypanosomes sustain transmission populations?

Ancestral aneuploidy and stable chromosomal duplication resulting in differential genome structure and gene expression control in trypanosomatid parasites

AAK1‐like: A putative pseudokinase with potential roles in cargo uptake in bloodstream form Trypanosoma brucei parasites

Immunoprecipitation of RNA-DNA hybrid interacting proteins in Trypanosoma brucei reveals conserved and novel activities, including in the control of surface antigen expression needed for immune evasion by antigenic variation

Single-cell transcriptomic analysis of bloodstream Trypanosoma brucei reconstructs cell cycle progression and developmental quorum sensing.

The MRN complex promotes DNA repair by homologous recombination and restrains antigenic variation in African trypanosomes

Genome duplication in Leishmania major relies on persistent subtelomeric DNA replication

Genome maintenance functions of a putative Trypanosoma brucei translesion DNA polymerase include telomere association and a role in antigenic variation

Conditional knockout of RAD51-related genes in Leishmania major reveals a critical role for homologous recombination during genome replication

Collaborators (9)

Kathryn Crouch

Federico Rojas

Daniel Jeffares

Thomas Otto

Graham Hamilton

Catarina de Almeida Marques

Professor Keith Matthews FRS FMedSci FRSE

Gabriel Lamak Almeida Da Silva

Dario Beraldi

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