Robert Edwards

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Associate Professor

Duke University

United States

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Robert Edwards is an Associate Professor at Duke University, USA. His research focuses on immunology and virology, with recent articles addressing broadly neutralizing antibodies against SARS-CoV-2 and HIV-1. He explores various vaccination strategies and the dynamics of viral proteins, aiming to enhance immunogenic responses and antibody development.

Recent Grants

Grant: Close

Structural Dynamics of Stretch Activation in Muscle

Open Date: 2012-09-15

Close Date: 2017-08-31

Grant: Close

Myofibrillar Structure of Striated Muscle

Open Date: 1979-05-01

Close Date: 2017-07-31

Articles (20)

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2022

Collaborators (12)

Simon Brackenridge

University of Oxford

UNITED KINGDOM

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Pedro D. Manrique

Assistant Professor

Florida Polytechnic University

UNITED STATES

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Kevin Saunders

Duke University

UNITED STATES

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Rory Henderson

Assistant Professor

Duke University

UNITED STATES

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sophie gobeil

Laval University

CANADA

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David R. Martinez

University of North Carolina at Chapel Hill

UNITED STATES

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Rachael Mansbach

Assistant Professor

Concordia University

CANADA

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Karl Harlos

University of Oxford

UNITED KINGDOM

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Barton F. Haynes

Duke University Medical Center

UNITED STATES

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Scott Sherrill-Mix

Assistant professor

Michigan State University

UNITED STATES

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Beatrice H. Hahn

University of Pennsylvania

UNITED STATES

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Yanshun Liu

Duke University

UNITED STATES

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Robert Edwards

Research Interests

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About

Recent Grants

Articles (20)

An engineered immunogen activates diverse HIV broadly neutralizing antibody precursors and promotes acquisition of improbable mutations

Nonstabilized SARS-CoV-2 spike mRNA vaccination induces broadly neutralizing antibodies in nonhuman primates.

Acquisition of quaternary trimer interaction as a key step in the lineage maturation of a broad and potent HIV-1 neutralizing antibody.

Microsecond dynamics control the HIV-1 Envelope conformation

Isolation and characterization of IgG3 glycan-targeting antibodies with exceptional cross-reactivity for diverse viral families.

Comparison of the immunogenicity of mRNA-encoded and protein HIV-1 Env-ferritin nanoparticle designs.

SARS-CoV-2 Omicron XBB lineage spike structures, conformations, antigenicity, and receptor recognition.

Non-neutralizing SARS-CoV-2 N-terminal domain antibodies protect mice against severe disease using Fc-mediated effector functions.

Vaccine induction of heterologous HIV-1-neutralizing antibody B cell lineages in humans.

Vaccine induction of CD4-mimicking HIV-1 broadly neutralizing antibody precursors in macaques.

Network analysis uncovers the communication structure of SARS-CoV-2 spike protein identifying sites for immunogen design

Structure-Based Stabilization of SOSIP Env Enhances Recombinant Ectodomain Durability and Yield.

A Germline-Targeting Chimpanzee SIV Envelope Glycoprotein Elicits a New Class of V2-Apex Directed Cross-Neutralizing Antibodies.

Breadth of SARS-CoV-2 neutralization and protection induced by a nanoparticle vaccine.

Stabilized HIV-1 envelope immunization induces neutralizing antibodies to the CD4bs and protects macaques against mucosal infection.

An antibody from single human VH-rearranging mouse neutralizes all SARS-CoV-2 variants through BA.5 by inhibiting membrane fusion.

Cryo-EM structures of SARS-CoV-2 Omicron BA.2 spike.

Mouse and human antibodies bind HLA-E-leader peptide complexes and enhance NK cell cytotoxicity.

Structural diversity of the SARS-CoV-2 Omicron spike.

mRNA-encoded HIV-1 Env trimer ferritin nanoparticles induce monoclonal antibodies that neutralize heterologous HIV-1 isolates in mice.

Collaborators (12)

Simon Brackenridge

Pedro D. Manrique

Kevin Saunders

Rory Henderson

sophie gobeil

David R. Martinez

Rachael Mansbach

Karl Harlos

Barton F. Haynes

Scott Sherrill-Mix

Beatrice H. Hahn

Yanshun Liu

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