Robert G. Frykberg

Aims Contralateral temperature difference (CTD) is a frequently used marker of healing in Charcot neuro‐osteoarthropathy (CN). We aimed to determine whether there is a consistent approach to CTD measurement during healing and the decision‐making process around cessation of immobilisation. Materials and Methods Medline, Scopus, and Web of Science were searched until February 2022 for peer‐reviewed studies using keywords, including ((‘arthropathy’ OR ‘osteoarthropathy’ OR ‘osteopathy’ OR ‘neuroarthropathy’) AND ‘Charcot’ AND (‘temperature’)), which returned 789 results excluding duplicates. Included studies monitored CTD in those with active CN to (i) assess the healing process and (ii) assist in determining the transition from immobilisation. Results Thirty four studies in total ( n = 677 participants) were shortlisted and 19 were included after full paper review. Average CTD at presentation varied from 1.6 to 8.0°C with insufficient data to determine if CTD was proportional to severity of Charcot. Evidence of a relationship between CTD and radiographic or scintigraphy‐based markers of healing varied depending on the methodology employed. Threshold CTD for the cessation of immobilisation ranged from <1°C to <2°C. Most frequently it was <2°C sustained for 2–3 visits. Temperature was monitored typically every 2–6 weeks using handheld thermometry at CN site(s) after resting the feet for 15 min. Device type, accuracy/reliability, and ambient temperature were rarely reported. Conclusions Further research on CTD and radiographic and radiotracer markers is needed involving larger cohorts. Standardisation in reporting of thermometry device type, accuracy and reliability, foot resting times, and ambient temperature controls is essential to facilitate the comparison of studies, meta‐analysis, and evaluation of different immobilisation interventions.