Robert Mach

Britton Chance Professor

University of Pennsylvania

United States

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About

Robert Mach is the Britton Chance Professor at the University of Pennsylvania in the United States. His research focuses on neurodegenerative diseases, particularly the imaging of proteinopathies associated with α-synuclein and tau using advanced PET techniques. Recent publications highlight his work on novel radioligands and non-invasive imaging methods to explore oxidative stress and biomarker identification in neurodegenerative models and conditions.

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Collaborators (15)

Michael CAHILL

Adjunct Senior Lecturer in Biochemistry and Cell Biology

Charles Sturt University

AUSTRALIA

Robert Mach

Research Interests

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Articles (22)

Ternary Complex Components Responsible for Rapid LDL Internalization as Biomarkers for Breast Cancer Associated with Proliferation and Early Recurrence

Discovery of <i>N</i>-(6-Methoxypyridin-3-yl)quinoline-2-amine Derivatives for Imaging Aggregated α-Synuclein in Parkinson’s Disease with Positron Emission Tomography

Structure–Activity Relationships and Evaluation of 2-(Heteroaryl-cycloalkyl)-1H-indoles as Tauopathy Positron Emission Tomography Radiotracers

Use of Amplified Lewy Body Dementia Fibrils and Autoradiography to Characterize Binding of Radioligand Tg-1-90B to Alpha-Synuclein Fibrils in Postmortem Brain Tissue

Novel Non-Invasive PET Imaging of Reactive Oxygen Species Using [18 F]ROStrace in Three Proteinopathy-Associated Neurodegenerative Mouse Models

Pilot Study of [<sup>11</sup>C]HY-2-15: A Mixed Alpha-Synuclein and Tau PET Radiotracer

A nanoluciferase complementation-based assay for monitoring β-arrestin2 recruitment to the dopamine D3 receptor

Noninvasive Detection of Oxidative Stress in a Mouse Model of 4R Tauopathy via Positron Emission Tomography with [18F]ROStrace

Total-body imaging of mu-opioid receptors with [11C]carfentanil in non-human primates

Positron Emission Tomography with [<sup>18</sup>F]ROStrace Reveals Progressive Elevations in Oxidative Stress in a Mouse Model of Alpha-Synucleinopathy

PET Imaging with [<sup>18</sup>F]ROStrace Detects Oxidative Stress and Predicts Parkinson’s Disease Progression in Mice

Sigma-2 Receptor Ligand Binding Modulates Association between TSPO and TMEM97

Synthesis of bitopic ligands based on fallypride and evaluation of their affinity and selectivity towards dopamine D2 and D3 receptors

In Silico Discovery and Subsequent Characterization of Potent 4R-Tauopathy Positron Emission Tomography Radiotracers

Selective Activation of D3 Dopamine Receptors Ameliorates DOI-Induced Head Twitching Accompanied by Changes in Corticostriatal Processing

Synthesis and Pharmacological Characterization of a Difluorinated Analogue of Reduced Haloperidol as a Sigma-1 Receptor Ligand

Computational Chemistry for the Identification of Lead Compounds for Radiotracer Development

Design and Synthesis of D3R Bitopic Ligands with Flexible Secondary Binding Fragments: Radioligand Binding and Computational Chemistry Studies

Design and Synthesis of Conformationally Flexible Scaffold as Bitopic Ligands for Potent D3-Selective Antagonists

Characterization of Sigma-2 Receptor—Specific Binding Sites Using [3H]DTG and [125I]RHM-4

[<sup>18</sup>F]NOS PET Brain Imaging Suggests Elevated Neuroinflammation in Idiopathic Parkinson’s Disease

Screening of σ2 Receptor Ligands and In Vivo Evaluation of 11C-Labeled 6,7-Dimethoxy-2-[4-(4-methoxyphenyl)butan-2-yl]-1,2,3,4-tetrahydroisoquinoline for Potential Use as a σ2 Receptor Brain PET Tracer

Collaborators (15)

Michael CAHILL

Nicoletta Resta

E. James Petersson

Carmen Abate

Steven Geib

Marialessandra Contino

Byung Chul Lee

Vittoria Infantino

Nunzio Denora

Ying Hwey Nai

Mauro Niso

Jeff Stehouwer

Lewis Chodosh

Chester Mathis

Elizabeth McDonald

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