Robert Pearce

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Professor

University of Wisconsin-Madison

United States

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Robert Pearce is a Professor at the University of Wisconsin Madison, United States. His research primarily focuses on neurodegeneration, cognitive function, and the effects of anesthesia on postoperative delirium, as evidenced by his recent articles. His work explores areas such as microglial activation, synaptic plasticity, and the association of biomarkers with cognitive deficits in postoperative patients.

Recent Grants

Grant: Close

Anesthetic Suppression of Memory through disinhibitory circuits in Hippocampus

Open Date: 2016-04-01

Close Date: 2020-03-31

Grant: Close

Inhaled Anesthestic Modulation of Hippocampal Circuits

Open Date: 2011-09-15

Close Date: 2016-05-31

Grant: Close

Clinical Neuroengineering Training Program

Open Date: 2011-04-01

Close Date: 2017-08-31

Grant: Close

Roles of GABAAR Subunits in Hippocampal Inhibition and Oscillations

Open Date: 2007-03-01

Close Date: 2012-02-28

Grant: Close

Volatile Anesthetic Actions on Synaptic GABAA Receptors

Open Date: 1997-05-01

Close Date: 2007-07-31

Articles (14)

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2025

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2023

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2022

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2022

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2022

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2022

Collaborators (5)

Matthew Banks

Professor

University of Wisconsin School of Medicine and Public Health

UNITED STATES

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Jennifer Taylor

The University of Sydney School of Medicine

AUSTRALIA

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Robert D Sanders

University of Sydney

AUSTRALIA

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Yuri Saalmann

Associate Professor

University of Wisconsin-Madison

UNITED STATES

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Maltesh Kambali

University of Illinois Urbana–Champaign

UNITED STATES

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Robert Pearce

Research Interests

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Recent Grants

Articles (14)

Noncanonical sustained actions of propofol reverse surgery-induced microglial activation and cognitive impairment in aged mice

The 3-Minute Diagnostic Confusion Assessment Method severity score correlates with the Delirium Rating Scale–Revised–98 and with biomarkers of delirium

GfapMutation and Astrocyte Dysfunction Lead to a Neurodegenerative Profile with Impaired Synaptic Plasticity and Cognitive Deficits in a Rat Model of Alexander Disease

Association of preoperative to postoperative change in cerebrospinal fluid fibrinogen with postoperative delirium

Resolution of elevated interleukin-6 after surgery is associated with return of normal cognitive function

Subanaesthetic doses of ketamine reduce but do not eliminate predictive coding responses: implications for mechanisms of sensory disconnection

Plasma HMGB1 levels in postoperative delirium

Prospective analysis of plasma amyloid beta and postoperative delirium in the Interventions for Postoperative Delirium: Biomarker-3 study

Changes in Memory, Sedation, and Receptor Kinetics Imparted by the β2-N265M and β3-N265M GABAA Receptor Point Mutations

Sevoflurane dose and postoperative delirium: a prospective cohort analysis

Dose-dependent suppression of hippocampal contextual memory formation, place cells, and spatial engrams by the NMDAR antagonist (R)-CPP

CPP impairs contextual learning at concentrations below those that block pyramidal neuron NMDARs and LTP in the CA1 region of the hippocampus

Amyloid deposition on positron emission tomography correlates with severity of perioperative delirium: a case-control pilot study

Distinct EEG signatures differentiate unconsciousness and disconnection during anaesthesia and sleep

Collaborators (5)

Matthew Banks

Jennifer Taylor

Robert D Sanders

Yuri Saalmann

Maltesh Kambali

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