Robert Sauer

Massachusetts Institute of Technology

United States

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Articles (14)

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2025

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2020

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2020

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2020

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2020

Collaborators (3)

Julia Kardon

Assistant Professor of Biochemistry

Brandeis University

UNITED STATES

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Alireza Ghanbarpour

Assistant Professor

Washington University School of Medicine

UNITED STATES

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Joseph H. Davis

Assistant Professor

Massachusetts Institute of Technology

UNITED STATES

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Robert Sauer

Research Interests

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Articles (14)

An asymmetric nautilus-like HflK/C assembly controls FtsH proteolysis of membrane proteins

Structural insights into the Pseudomonas aeruginosaClpP1•ClpP2 heterocomplex and its interactions with the AAA+ ClpX unfoldase

A proteolytic AAA+ machine poised to unfold protein substrates

The SspB adaptor drives structural changes in the AAA+ ClpXP protease during ssrA-tagged substrate delivery

FtsH degrades kinetically stable dimers of cyclopropane fatty acid synthase via an internal degron

A closed translocation channel in the substrate-free AAA+ ClpXP protease diminishes rogue degradation

AAA+ protease-adaptor structures reveal altered conformations and ring specialization

FtsH degrades dihydrofolate reductase by recognizing a partially folded species

Structure and function of ClpXP, a AAA+ proteolytic machine powered by probabilistic ATP hydrolysis

Division of labor between the pore-1 loops of the D1 and D2 AAA+ rings coordinates substrate selectivity of the ClpAP protease

ClpP1P2 peptidase activity promotes biofilm formation in P. aeruginosa.

ClpAP proteolysis does not require rotation of the ClpA unfoldase relative to ClpP

Multistep substrate binding and engagement by the AAA+ ClpXP protease

Structural basis of ClpXP recognition and unfolding of ssrA-tagged substrates

Collaborators (3)

Julia Kardon

Alireza Ghanbarpour

Joseph H. Davis

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