Roberto Contestabile

Associate Professor

Sapienza University of Rome

Italy

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About

Roberto Contestabile is an Associate Professor at Sapienza Università di Roma. His research primarily focuses on the biochemical roles of vitamin B6, including its interaction with metabolic processes in Drosophila and implications for human health. Recent articles highlight his investigations into the enzymatic functions and biochemical pathways associated with vitamin B6 and related compounds.

Articles (14)

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2025

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Collaborators (10)

Francesca Cutruzzola'

Full Professor of Molecular Biology

Università degli Studi di Roma La Sapienza

ITALY

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Bartosz Sekula

Lodz University of Technology

POLAND

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Alessandro Paiardini

Sapienza University of Rome

ITALY

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Giorgio Giardina

Associate Professor

Università degli Studi di Roma La Sapienza

ITALY

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Fiammetta Vernì

ITALY

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Angela Tramonti

ITALY

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Andrea Ilari

Istituto di Biologia e Patologia Molecolari Consiglio Nazionale delle Ricerche

ITALY

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José Antonio Encinar

Profesor Titular de Universidad

Universidad Miguel Hernández de Elche

SPAIN

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Maria Rutkiewicz

Assistant Professor (Adiunkt)

Polska Akademia Nauk Instytut Chemii Bioorganicznej

POLAND

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Catherine Lindon

University Lecturer

University of Cambridge

UNITED KINGDOM

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Roberto Contestabile

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Articles (14)

Vitamin B6 deficiency produces metabolic alterations in Drosophila

The Z isomer of pyridoxilidenerhodanine 5′‐phosphate is an efficient inhibitor of human pyridoxine 5′‐phosphate oxidase, a crucial enzyme in vitamin B6 salvage pathway and a potential chemotherapeutic target

Vitamin B6 deficiency cooperates with oncogenic Ras to induce malignant tumors in Drosophila

The ubiquitous pyridoxal 5′‐phosphate‐binding protein is also an RNA‐binding protein

Insights into the substrate specificity, structure, and dynamics of plant histidinol-phosphate aminotransferase (HISN6)

A gene‐nutrient interaction between vitamin B6 and serine hydroxymethyltransferase (SHMT) affects genome integrity in Drosophila

Arabidopsis thaliana serine hydroxymethyltransferases: functions, structures, and perspectives

Vitamin B6 rescues insulin resistance and glucose‐induced DNA damage caused by reduced activity of Drosophila PI3K

Metformin Is a Pyridoxal-5′-phosphate (PLP)-Competitive Inhibitor of SHMT2

PHA-680626 Is an Effective Inhibitor of the Interaction between Aurora-A and N-Myc

Characterization of Novel Pathogenic Variants Causing Pyridox(am)ine 5′-Phosphate Oxidase-Dependent Epilepsy

A Novel, Easy Assay Method for Human Cysteine Sulfinic Acid Decarboxylase

Functional Inactivation of Drosophila GCK Orthologs Causes Genomic Instability and Oxidative Stress in a Fly Model of MODY-2

Identification and characterization of the pyridoxal 5’-phosphate allosteric site in Escherichia coli pyridoxine 5’-phosphate oxidase

Collaborators (10)

Francesca Cutruzzola'

Bartosz Sekula

Alessandro Paiardini

Giorgio Giardina

Fiammetta Vernì

Angela Tramonti

Andrea Ilari

José Antonio Encinar

Maria Rutkiewicz

Catherine Lindon

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