Roly Megaw

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Clinical Lecturer

University of Edinburgh

United Kingdom

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About

Roly Megaw is a Clinical Lecturer at the University of Edinburgh, UK. His research primarily focuses on the molecular mechanisms of inherited retinal dystrophies, including topics such as single-cell transcriptomics, autophagy disruption, and photoreceptor integrity. He has also investigated the impacts of microvascular disease on severe COVID-19 outcomes among diabetic patients.

Recent Grants

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Towards in vivo genome editing of post-mitotic mammalian photoreceptors for treatment of Inherited Retinal Dystrophies

Open Date: 2019-04-01

Close Date: 2020-04-01

Grant: Close

Short-term salary for a Clinical Lecturer to enable career progression

Open Date: 2017-08-01

Close Date: 2018-02-01

Grant: Close

The role of RPGR in photoreceptor actin dynamics

Open Date: 2017-01-01

Close Date: 2018-01-01

Grant: Close

In vivo correction of human retinitis pigmentosa mutations in a mouse model

Open Date: 2016-06-01

Close Date: 2018-06-01

Grant: Close

In vivo correction of a human mutation in a mouse model of retinitis pigmentosa

Open Date: 2016-02-01

Close Date: 2018-02-01

Articles (18)

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2025

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2022

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2022

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2022

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2021

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2020

Collaborators (19)

Ian MacCormick

SCREDS Clinical Lecturer (ophthalmology)

University of Edinburgh

UNITED KINGDOM

Roly Megaw

Research Interests

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About

Recent Grants

Articles (18)

XOLARIS: A 24-Month, Prospective, Natural History Study of 201 Participants with Retinitis Pigmentosa GTPase Regulator-Associated X-Linked Retinitis Pigmentosa

Single-Cell Transcriptomics in Inherited Retinal Dystrophies: Current Findings and Emerging Perspectives

Autophagy disruption and mitochondrial stress precede photoreceptor necroptosis in multiple mouse models of inherited retinal disorders.

Photoreceptor Disc Morphogenesis: Who Are the Conductors of This Highly Metronomic Process?

Ciliopathy patient variants reveal organelle-specific functions for TUBB4B in axonemal microtubules

Ciliary tip actin dynamics regulate photoreceptor outer segment integrity

UVR and RPE – The Good, the Bad and the degenerate Macula

Microvascular disease and severe COVID-19 outcomes in UKBiobank participants with diabetes.

Molecular Mechanisms Governing Sight Loss in Inherited Cone Disorders

Centriolar satellites expedite mother centriole remodeling to promote ciliogenesis

Impact of the COVID-19 pandemic on the research activities of UK ophthalmologists

Anterior segment phenotypic changes in late-onset retinal degeneration with Ser163Arg mutation in CTRP5/C1QTNF5.

Treatment Strategy With Gene Editing for Late-Onset Retinal Degeneration Caused by a Founder Variant in C1QTNF5.

BBS1 branchpoint variant is associated with non-syndromic retinitis pigmentosa

Pre-existing diabetic retinopathy as a prognostic factor for COVID-19 outcomes amongst people with diabetes: A systematic review

Emerging Gene Manipulation Strategies for the Treatment of Monogenic Eye Disease.

A Systematic Review and Meta-Analyses of Interventional Clinical Trial Studies for Gene Therapies for the Inherited Retinal Degenerations (IRDs).

Mechanisms of Photoreceptor Death in Retinitis Pigmentosa.

Collaborators (19)

Ian MacCormick

Marisa Ferreira

Ajoy Vincent

Pleasantine Mill

pierre bagnaninchi

Richard Weller

Jasleen Jolly

Jacque Duncan

Jacob Anderson

Catalina A. Vallejos

Stefan Unger

Christian Gilissen

Abigail Moye

Jean‐Michel Rozet

Catherina Li

Jamie Ellingford

Carlos E Mendoza-Santiesteban

Jay Self

Amelia Shoemark

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