Rowan Karvas

Assistant Professor

University of Colorado Cancer Center

United States

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About

Rowan Karvas is an Assistant Professor at the University of Colorado Anschutz Medical Campus Cancer Center in the United States. His research encompasses areas including pluripotent stem cell biology, human embryogenesis, and trophoblast differentiation. Recent publications highlight his work on three-dimensional culturing techniques and the molecular mechanisms guiding early placental development.

Articles (7)

Year:

2024

Year:

2023

Year:

2023

Year:

2022

Year:

2022

Year:

2022

Year:

2020

Collaborators (1)

Thorold Theunissen

Assistant Professor

Washington University in Saint Louis School of Medicine

UNITED STATES

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Rowan Karvas

Research Interests

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Articles (7)

Self-renewing human naïve pluripotent stem cells dedifferentiate in 3D culture and form blastoids spontaneously.

3D-cultured blastoids model human embryogenesis from pre-implantation to early gastrulation stages.

The immune checkpoint molecule, VTCN1/B7-H4, guides differentiation and suppresses proinflammatory responses and MHC class I expression in an embryonic stem cell-derived model of human trophoblast.

Accessing the human trophoblast stem cell state from pluripotent and somatic cells

A genome-wide CRISPR-Cas9 knockout screen identifies essential and growth-restricting genes in human trophoblast stem cells

Stem-cell-derived trophoblast organoids model human placental development and susceptibility to emerging pathogens

Use of a human embryonic stem cell model to discover GABRP, WFDC2, VTCN1 and ACTC1 as markers of early first trimester human trophoblast

Collaborators (1)

Thorold Theunissen

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