Russell Rockne

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Associate Professor, Director, Vice Chair

United States

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About

Russell Rockne serves as an Associate Professor and Director at the Beckman Research Institute, City of Hope National Medical Center in the United States. His research primarily focuses on glioblastoma dynamics, cancer immune escape mechanisms, and predictive modeling in breast cancer treatment. Recent publications include studies on CAR T-cell therapy, interstitial fluid transport in glioblastoma, and novel pharmacological approaches targeting cancer cells.

Recent Grants

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The impact of interstitial fluid flow on CAR T cell trafficking, distribution, and efficacy

Open Date: 2021-06-15

Close Date: 2026-03-31

Grant: Close

Information flow and state transitions at the system and multi-dimensional scales in leukemia progression

Open Date: 2020-05-01

Close Date: 2025-04-30

Grant: Close

Experimental-Computational Synthesis of Altered Immune Signaling in Breast Cancer

Open Date: 2019-09-16

Close Date: 2024-08-31

Grant: Close

Exploring the preclinical relevance of therapeutic radiolabeled daratumumab (anti-CD38) in combination with anti-CS1 CAR T cells as a novel combinatorial treatment for multiple myeloma

Open Date: 2019-08-01

Close Date: 2024-07-31

Grant: Close

Development and validation of a computational prediction model for exogenous neural stem cell migration to sites of brain tumors

Open Date: 2018-07-01

Close Date: 2020-06-30

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UNITED STATES

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Denis O'Meally

Assistant Research Professor

Beckman Research Institute, City of Hope

UNITED STATES

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Aleksandra Karolak

Assistant Professor

Moffitt Cancer Center

UNITED STATES

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Russell Rockne

Research Interests

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Recent Grants

Articles (20)

CAR T-cell and oncolytic virus dynamics and determinants of combination therapy success for glioblastoma

Interstitial fluid transport dynamics predict glioblastoma invasion and progression

Use of AlphaFold 2 to predict stabilizing mutations for the R337H variant in the tetramerization domain of TP53.

Pharmacological activity of OST-01, a natural product from baccharis coridifolia, on breast cancer cells

miR-142 deficit in T cells during blast crisis promotes chronic myeloid leukemia immune escape

Validation of Clinical Dynamic Contrast-Enhanced Magnetic Resonance Imaging Perfusion Modeling and Neoadjuvant Chemotherapy Response Prediction in Breast Cancer Using 18 FDG and 64 Cu-DOTA-Trastuzumab Positron Emission Tomography Studies

Challenges with sirolimus experimental data to inform QSP model of post‐transplantation cyclophosphamide regimens

CNSC-54. CENTRAL AND BOUNDARY-DRIVEN GROWTH PATTERNS DOMINATE RESPECTIVELY IDH WILD-TYPE AND MUTANT GLIOMAS

Mathematical Modeling Unveils Optimization Strategies for Targeted Radionuclide Therapy of Blood Cancers

Systems profiling reveals recurrently dysregulated cytokine signaling responses in ER+ breast cancer patients’ blood

Modeling interaction of Glioma cells and CAR T-cells considering multiple CAR T-cells bindings

Proteomics and mathematical modeling of longitudinal CSF differentiates fast versus slow ALS progression

Differential Distribution of Brain Metastases from Non-Small Cell Lung Cancer Based on Mutation Status

Sequential CAR T cell and targeted alpha immunotherapy in disseminated multiple myeloma

Data driven model discovery and interpretation for CAR T-cell killing using sparse identification and latent variables

Bow-tie architectures in biological and artificial neural networks: implications for network evolution and assay design

Integration of single-cell transcriptomes and biological function reveals distinct behavioral patterns in bone marrow endothelium

Regulation of chromatin accessibility by the histone chaperone CAF-1 sustains lineage fidelity

Spatial organization of heterogeneous immunotherapy target antigen expression in high-grade glioma

Comparison of cell state models derived from single-cell RNA sequencing data: graph versus multi-dimensional space.

Collaborators (7)

Heyrim Cho

Wang Qixuan

Alexander Brummer

Yingjun Luo

Guofang Shen

Denis O'Meally

Aleksandra Karolak

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