Ruth Barrientos

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Associate Professor

Ohio State University

United States

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About

Ruth Barrientos is an Associate Professor at The Ohio State University in the United States. Her research focuses on the vulnerabilities associated with the aging brain, particularly its susceptibility to inflammatory challenges and memory dysfunction. Recent publications include works on the effects of high-fat diets on cognitive function, the role of microglia in immune response, and the impact of dietary factors on cognitive health in both young and aged models.

Recent Grants

Grant: Close

Exploring HFD-induced alterations in long-term potentiation in aged hippocampus and amygdala

Open Date: 2020-04-15

Close Date: 2022-03-31

Grant: Close

The impact of aging on cancer-related cognitive comorbidities and mechanisms

Open Date: 2018-01-01

Close Date: 2019-12-01

Grant: Close

The impact of aging on cancer-related cognitive comorbidities and mechanisms

Open Date: 2018-01-01

Close Date: 2020-12-31

Grant: Close

Neuroinflammation, Inflammatory Challenge, and Memory

Open Date: 2006-08-01

Close Date: 2023-03-31

Grant: Close

Cytokines and Memory Consolidation

Open Date: 2001-12-27

Close Date: 2004-12-26

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2020

Collaborators (1)

Peter Grace

Associate Professor

The University of Texas MD Anderson Cancer Center

UNITED STATES

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Ruth Barrientos

Research Interests

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About

Recent Grants

Articles (20)

Dr. Steven F. Maier: A fearless scientist, a rigorous mentor, and a legacy of excellence

Post-operative cognitive dysfunction is exacerbated by high-fat diet via TLR4 and prevented by dietary DHA supplementation

Ruth M. Barrientos: Vulnerabilities associated with the aging brain that make it more susceptible to inflammatory challenges leading to memory dysfunction

Short-term high-fat diet consumption impairs synaptic plasticity in the aged hippocampus via IL-1 signaling

Selective TLR4 Antagonism Prevents and Reverses Morphine-Induced Persistent Postoperative Cognitive Dysfunction, Dysregulation of Synaptic Elements, and Impaired BDNF Signaling in Aged Male Rats

Dietary fatty acids differentially impact phagocytosis, inflammatory gene expression, and mitochondrial respiration in microglial and neuronal cell models.

The role of microglia in 67NR mammary tumor-induced suppression of brain responses to immune challenges in female mice.

Young adult and aged female rats are vulnerable to amygdala-dependent, but not hippocampus-dependent, memory impairment following short-term high-fat diet.

CD8<sup>+</sup> T cells contribute to diet-induced memory deficits in aged male rats.

Evolution of the Human Diet and Its Impact on Gut Microbiota, Immune Responses, and Brain Health

The Perfect Cytokine Storm: How Peripheral Immune Challenges Impact Brain Plasticity & Memory Function in Aging.

Dietary DHA prevents cognitive impairment and inflammatory gene expression in aged male rats fed a diet enriched with refined carbohydrates.

Elevated Expression of MiR-17 in Microglia of Alzheimer's Disease Patients Abrogates Autophagy-Mediated Amyloid-β Degradation.

Post-operative cognitive dysfunction is made persistent with morphine treatment in aged rats

Lifestyle modifications with anti-neuroinflammatory benefits in the aging population.

Experimental autoimmune encephalopathy (EAE)-induced hippocampal neuroinflammation and memory deficits are prevented with the non-opioid TLR2/TLR4 antagonist (+)-naltrexone.

Reply to the Letter to the Editor: Regional differences in dietary use of immune-modulating catechins should be investigated regarding COVID-19.

Fatty food, fatty acids, and microglial priming in the adult and aged hippocampus and amygdala.

The impact of nutrition on COVID-19 susceptibility and long-term consequences.

Collapsin Response Mediator Proteins: Novel Targets for Alzheimer's Disease.

Collaborators (1)

Peter Grace

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