Ryan Altman

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Professor

Purdue University

United States

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About

Ryan Altman is a Professor at Purdue University, located in the United States. His research interests encompass enantioselective synthesis, oxidative dearomatization mechanisms, and the development of interaction inhibitors using innovative assays. He has recently published articles exploring various synthetic strategies and high-throughput screening techniques, contributing significantly to the fields of organic and medicinal chemistry.

Recent Grants

Grant: Close

Identification of CNS-Penetrant Tryptophan 2,3-Dioxygenase Degrading Ligands

Open Date: 2022-09-01

Close Date: 2024-06-30

Grant: Close

Targeting Tryptophan Dioxygenase Degradation for Suppression of Tumor Immune Evasion

Open Date: 2022-02-01

Close Date: 2024-01-31

Grant: Close

Fluoroalkylethers and Fluorinated Ethermimetics

Open Date: 2017-08-01

Close Date: 2022-07-31

Grant: Open

Fluorination and Fluoroalkylation Strategies for Synthetic and Medicinal Chemistry

Open Date: 2017-08-01

Close Date: 2027-07-31

Grant: Close

Evaluation of Physicochemical Properties Imparted by Fluorinated Peptidomimetics

Open Date: 2017-05-01

Close Date: 2019-04-30

Articles (20)

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2022

Collaborators (4)

Giuseppe La Regina

Sapienza University of Rome

ITALY

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Jennifer Golden

Associate Professor of Pharmaceutical Sciences and Associate Director, UW Medicinal Chemistry Center

University of Wisconsin-Madison

UNITED STATES

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Cody Loy

University of California, Irvine

UNITED STATES

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Terry Moore

Associate Professor

University of Chicago

UNITED STATES

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Ryan Altman

Research Interests

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About

Recent Grants

Articles (20)

Unified Enantioselective Synthesis of 5-Phenylmorphans and cis-Octahydroisoquinolines

NBS-Promoted Synthesis of Maleimides by Oxidative Dearomatization of Pyrroles: Mechanistic Investigations Using Online MS in Real-Time

Discovery of RGS2-FBXO44 interaction inhibitors using a cell-based NanoBit assay

A deoxyfluoroalkylation–aromatization strategy to access fluoroalkyl arenes

Deoxytrifluoromethylation/aromatization of cyclohexan(en)ones to access highly substituted trifluoromethyl arenes

A Phenotypic High-Throughput Screen Identifies Small Molecule Modulators of Endogenous RGS10 in BV-2 Cells

α-Amino-β-carboxymuconate-ε-semialdehyde decarboxylase catalyzes enol/keto tautomerization of oxaloacetate

Palladium and copper co-catalyzed chloro-arylation of gem-difluorostyrenes – use of a nitrite additive to suppress β-F elimination

Palladium and copper co-catalyzed chloro-arylation of gem-difluorostyrenes - use of a nitrite additive to suppress β-F elimination

In This Issue, Volume 14, Issue 9

Palladium-Catalyzed Dearomatization of Benzothiophenes: Isolation and Functionalization of a Discrete Dearomatized Intermediate

A diselenide additive enables photocatalytic hydroalkoxylation of gem-difluoroalkenes

Peroxide-Initiated Hydrophosphinylation of gem-Difluoroalkenes

General Co-catalytic Hydrothiolation of gem-Difluoroalkenes

In This Issue, Volume 13, Issue 12

β-Elimination rules for Pd

Cu(II)-Catalyzed Unsymmetrical Dioxidation of gem-Difluoroalkenes to Generate α,α-Difluorinated-α-phenoxyketones

An Innovation 10 Years in the Making: The Stories in the Pages of ACS Medicinal Chemistry Letters

Fluoroalkylation of Dextromethorphan Improves CNS Exposure and Metabolic Stability

In This Issue, Volume 13, Issue 3

Collaborators (4)

Giuseppe La Regina

Jennifer Golden

Cody Loy

Terry Moore

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