Saeed Daneshmandi

Research Assistant Professor of Oncology

Roswell Park Comprehensive Cancer Center

United States

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About

Dr. Saeed Daneshmandi is a Research Assistant Professor of Oncology at Roswell Park Comprehensive Cancer Center, located in the United States. His research focuses on the dynamics of the tumor microenvironment, particularly the roles of myeloid-derived suppressor cells and T cell metabolism in immunosuppression and cancer treatment efficacy. Recent articles authored by Dr. Daneshmandi explore topics including neutrophil dynamics, mitochondrial fitness of immune cells, and immune modulation within hematologic malignancies and solid tumors.

Articles (8)

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2025

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2024

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2024

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2023

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2022

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2021

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UNITED STATES

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Saeed Daneshmandi

Research Interests

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Articles (8)

Deciphering neutrophil dynamics in the focal lesion tumor microenvironment to overcome immunosuppression in multiple myeloma

Myeloid-derived suppressor cell mitochondrial fitness governs chemotherapeutic efficacy in hematologic malignancies

Exportin 1 governs the immunosuppressive functions of myeloid-derived suppressor cells in tumors through ERK1/2 nuclear export

Galectin-3 expression in donor T cells reduces GvHD severity and lethality after allogeneic hematopoietic cell transplantation

Polarization and β-Glucan Reprogram Immunomodulatory Metabolism in Human Macrophages and Ex Vivo in Human Lung Cancer Tissues

6-Phosphogluconate dehydrogenase (6PGD), a key checkpoint in reprogramming of regulatory T cells metabolism and function

Innate immune activation by checkpoint inhibition in human patient-derived lung cancer tissues

Blockade of 6-phosphogluconate dehydrogenase generates CD8<sup>+</sup> effector T cells with enhanced anti-tumor function

Collaborators (6)

Teresa Fan

Qi Yan

Andrew Lane

Hemn Mohammadpour

Richard Higashi

Romain Lannes

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