Sai Reddy

Assistant Professor

Eidgenössische Technische Hochschule Zürich

Switzerland

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About

Dr. Sai Reddy is an Assistant Professor at Eidgenössische Technische Hochschule Zürich, Switzerland. His research areas include T cell activation, antibody engineering, and protein-protein interactions, as evidenced by his recent contributions to the fields of immunotherapy and machine learning applications in protein engineering. Dr. Reddy has published significant works on topics such as TCR cross-reactivity, antibody repertoires, and the use of synthetic evolution in advancing antibody technologies.

Articles (14)

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2025

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2024

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2024

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2022

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2022

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2022

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2021

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2021

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2021

Collaborators (6)

Kenneth Hoehn

Assistant Professor

Dartmouth College

UNITED STATES

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K. Christopher Garcia

Stanford University School of Medicine

UNITED STATES

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Alfred Zippelius

SWITZERLAND

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Max Daniel Overath

Technical University of Denmark

DENMARK

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Maria Rodriguez Martinez

Associate Professor

Yale University

UNITED STATES

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Raphael Kuhn

ETH Zürich

SWITZERLAND

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Sai Reddy

Research Interests

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Articles (14)

Dissecting the role of CAR signaling architectures on T cell activation and persistence using pooled screens and single-cell sequencing

The physiological landscape and specificity of antibody repertoires are consolidated by multiple immunizations

Advancing Antibody Engineering through Synthetic Evolution and Machine Learning

The unexpected benefit of TCR cross-reactivity in cancer immunotherapy

Deploying synthetic coevolution and machine learning to engineer protein-protein interactions

Nucleotide augmentation for machine learning-guided protein engineering

Quantification of extracellular proteins, protein complexes and mRNAs in single cells by proximity sequencing

Deep mutational learning predicts ACE2 binding and antibody escape to combinatorial mutations in the SARS-CoV-2 receptor-binding domain

High-throughput T cell receptor engineering by functional screening identifies candidates with enhanced potency and specificity

Discovery and validation of human genomic safe harbor sites for gene and cell therapies

Phenotypic determinism and stochasticity in antibody repertoires of clonally expanded plasma cells

Leveraging Single-Cell Sequencing for Chimeric Antigen Receptor T Cell Therapies

Enhancing the Surface Quality and Tribomechanical Properties of AA 6061-T6 Friction Stir Welded Joints Reinforced with Varying SiC Contents

Optimization of therapeutic antibodies by predicting antigen specificity from antibody sequence via deep learning

Collaborators (6)

Kenneth Hoehn

K. Christopher Garcia

Alfred Zippelius

Max Daniel Overath

Maria Rodriguez Martinez

Raphael Kuhn

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