Salvatore Santamaria

Lecturer in Cardiovascular Science

University of Surrey

United Kingdom

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Salvatore Santamaria is a Lecturer in Cardiovascular Science at the University of Surrey, UK. His research primarily focuses on the role of ADAMTS proteoglycanases in cardiovascular diseases, with recent work exploring their activity and implications in aortic disease and osteoarthritis. His publications include studies on biomarkers of extracellular matrix remodeling and innovative approaches to targeting metalloproteinases for therapeutic applications.

Articles (15)

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2025

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2021

Collaborators (8)

Roberta Moschini

University of Pisa

ITALY

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Kimberly Alonge

Associate Professor

University of Florida

UNITED STATES

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James T. B. Crawley

Imperial College London

UNITED KINGDOM

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Elisa Nuti

Associate Professor

University of Pisa

ITALY

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Cristina Lo Celso

Imperial College London

UNITED KINGDOM

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Pedro Rodriguez Cutillas

Professor of Cell Signalling & Proteomics

Barts Cancer Institute

UNITED KINGDOM

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Armando Rossello

Full Professor

University of Pisa

ITALY

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Delfim Duarte

Invited Assistant Professor

PORTUGAL

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Salvatore Santamaria

Research Interests

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Articles (15)

Characterization of ADAMTS9 proteoglycanase activity: Comparison with ADAMTS1, ADAMTS4, and ADAMTS5

Versican Associates with Tumor Immune Phenotype and Limits T-cell Trafficking via Chondroitin Sulfate

Design, synthesis and biological evaluation of arylsulfonamides as ADAMTS7 inhibitors

Soluble Proteoglycans and Proteoglycan Fragments as Biomarkers of Pathological Extracellular Matrix Remodeling

The Role of ADAMTS Proteoglycanases in Thoracic Aortic Disease

The C-terminal domains of ADAMTS1 contain exosites involved in its proteoglycanase activity

Novel Approaches for Targeting Metalloproteinases

Metalloproteinase inhibition reduces AML growth, prevents stem cell loss, and improves chemotherapy effectiveness.

Targeting Aggrecanases for Osteoarthritis Therapy: From Zinc Chelation to Exosite Inhibition

A top-down approach to uncover the hidden ligandome of low-density lipoprotein receptor-related protein 1 in cartilage

Laminin G1 residues of protein S mediate its TFPI cofactor function and are competitively regulated by C4BP

Development of a fluorogenic ADAMTS-7 substrate

Exosite inhibition of ADAMTS-5 by a glycoconjugated arylsulfonamide

Editorial: ADAM, ADAMTS and Astacin Proteases: Challenges and Breakthroughs in the -Omics Era

Identification of novel ADAMTS1, ADAMTS4 and ADAMTS5 cleavage sites in versican using a label-free quantitative proteomics approach

Collaborators (8)

Roberta Moschini

Kimberly Alonge

James T. B. Crawley

Elisa Nuti

Cristina Lo Celso

Pedro Rodriguez Cutillas

Armando Rossello

Delfim Duarte

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