Samy Meroueh

Associate Professor

Indiana University School of Medicine

United States

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Dr. Samy Meroueh is an Associate Professor at Indiana University School of Medicine, USA. His research focuses on the development of small-molecule inhibitors targeting various protein interactions involved in cancer signaling pathways, including the TEAD·YAP1 transcription factor and RAS signaling. His recent publications highlight innovative strategies for covalent stabilization and inhibition of key cellular processes, contributing to the field of cancer therapeutics.

Articles (10)

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2025

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2025

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2023

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2023

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2023

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2023

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2023

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2022

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2021

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2021

Collaborators (1)

Giovanni Gonzalez-Gutierrez

Indiana University Bloomington

UNITED STATES

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Samy Meroueh

Research Interests

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Articles (10)

Small-Molecule Covalent Stabilization and Inhibition of the TEAD·YAP1 Transcription Factor in Cancer Cells

Small‐Molecule KRAS Inhibitors by Tyrosine Covalent Bond Formation

Exploring Covalent Bond Formation at Tyr‐82 for Inhibition of Ral GTPase Activation

Covalent Fragment Inhibits RhoA Activation by Guanine Exchange Factors

Small-Molecule Cyanamide Pan-TEAD·YAP1 Covalent Antagonists

Chloroacetamide fragment library screening identifies new scaffolds for covalent inhibition of the TEAD·YAP1 interaction

Crystal Packing Reveals a Potential Autoinhibited KRAS Dimer Interface and a Strategy for Small-Molecule Inhibition of RAS Signaling

Covalent Fragment Screening Identifies Rgl2 RalGEF Cysteine for Targeted Covalent Inhibition of Ral GTPase Activation

Small‐Molecule Inhibition of the uPAR ⋅ uPA Interaction by Conformational Selection

Design and Synthesis of Fragment Derivatives with a Unique Inhibition Mechanism of the uPAR·uPA Interaction

Collaborators (1)

Giovanni Gonzalez-Gutierrez

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