Sandro Cosconati

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Full Professor

University of Campania “Luigi Vanvitelli”

Italy

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About

Dr. Sandro Cosconati is a Full Professor at the University of Campania "Luigi Vanvitelli" in Italy. His research focuses on novel therapeutic agents, including dipeptide nitriles, inhibitors for endothelial nitric oxide synthase, and dual modulators with neurotrophic activity. He has also contributed to advancements in nucleic acid vaccines and sustainable peptide synthesis methodologies. His recent work showcases innovative approaches to drug development and disease prevention.

Recent Grants

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Pursuing new horizons for cancer therapy through the integration of innovative high-throughput drug-screening and rational drug-discovery

Open Date: 2014-02-01

Close Date: 2016-02-01

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Collaborators (12)

Roberta Ettari

University of Messina

ITALY

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Salvatore Di Maro

University of Campania “Luigi Vanvitelli”

ITALY

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Maria Zappalà

University of Messina

ITALY

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Antonella Messore

Link Campus University

ITALY

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Mariano Stornaiuolo

Associate Professor

University of Naples Federico II

ITALY

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Annabelle Carolin Weldert

Johannes Gutenberg Universität Mainz

GERMANY

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Ettore Novellino

Catholic University of the Sacred Heart

ITALY

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luigi scipione

Associate Professor

Università degli Studi di Roma La Sapienza

ITALY

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SANTO PREVITI

Vrije Universiteit Brussel

BELGIUM

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Fabiola De Luca

University of Messina

ITALY

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stefano tomassi

Associate Professor

Link Campus University

ITALY

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Sabrina Taliani

University of Pisa

ITALY

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Sandro Cosconati

Research Interests

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About

Recent Grants

Articles (26)

Trimethylamine N-Oxide (TMAO) Acts as Inhibitor of Endothelial Nitric Oxide Synthase (eNOS) and Hampers NO Production and Acetylcholine-Mediated Vasorelaxation in Rat Aortas

Synthesis and Combination Studies of Novel Dipeptide Nitriles with Curcumin for a Potent Synergistic Action Against Rhodesain, Cysteine Protease of Trypanosoma brucei rhodesiense

2-(Phenylamino)-7,8-dihydroquinazolin-5(6H)-one, a promising scaffold for MAO-B inhibitors with potential GSK3β targeting

Discovery of the First-in-Class Dual TSPO/Carbonic Anhydrase Modulators with Promising Neurotrophic Activity

From genetic code to global health: the impact of nucleic acid vaccines on disease prevention and treatment

From genetic code to global health: the impact of nucleic acid vaccines on disease prevention and treatment

Identification of constrained peptidomimetics carrying a Michael acceptor warhead as antitrypanosomal agents

Identification of isoxazole-based TRPA1 inhibitors with analgesic effects in vivo

Sustainable Ultrasound-Assisted Solid-Phase peptide synthesis (SUS-SPPS): Less Waste, more efficiency

Unveiling the role of poly(vinyl alcohol) in the production of mucus-penetrating PLGA nanoparticles

Identification of Dual Inhibitors Targeting Main Protease (M<sup>pro</sup>) and Cathepsin L as Potential Anti-SARS-CoV-2 Agents

Development of Novel Peptidyl Nitriles Targeting Rhodesain and Falcipain-2 for the Treatment of Sleeping Sickness and Malaria

Quinolinonyl Derivatives as Dual Inhibitors of the HIV-1 Integrase Catalytic Site and Integrase–RNA interactions

Discovering Dually Active Anti-cancer Compounds with a Hybrid AI-structure-based Approach.

Disulfide bond replacement with non-reducible side chain to tail macrolactamization for the development of potent and selective CXCR4 peptide antagonists endowed with flanking binding sites.

Streamlining Large Chemical Library Docking with Artificial Intelligence: the PyRMD2Dock Approach

A cyanine-based NIR fluorescent Vemurafenib analog to probe BRAF<sup>V600E</sup> in cancer cells

Structure-based lead optimization of peptide-based vinyl methyl ketones as SARS-CoV-2 main protease inhibitors

Ultrasound-assisted Peptide Nucleic Acids synthesis (US-PNAS)

Irreversible inhibition of TRF2TRFH recruiting functions by a covalent cyclic peptide induces telomeric replication stress in cancer cells

Development of Reduced Peptide Bond Pseudopeptide Michael Acceptors for the Treatment of Human African Trypanosomiasis

Development of Urea-Bond-Containing Michael Acceptors as Antitrypanosomal Agents Targeting Rhodesain

CLIPSing Melanotan-II to Discover Multiple Functionally Selective hMCR Agonists

Development of novel dipeptide nitriles as inhibitors of rhodesain of Trypanosoma brucei rhodesiense

FEPrepare: A Web-Based Tool for Automating the Setup of Relative Binding Free Energy Calculations

PyRMD: A New Fully Automated AI-Powered Ligand-Based Virtual Screening Tool

Collaborators (12)

Roberta Ettari

Salvatore Di Maro

Maria Zappalà

Antonella Messore

Mariano Stornaiuolo

Annabelle Carolin Weldert

Ettore Novellino

luigi scipione

SANTO PREVITI

Fabiola De Luca

stefano tomassi

Sabrina Taliani

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