Se Hoon Choi

Assistant Professor

Massachusetts General Hospital

United States

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Se Hoon Choi is an Assistant Professor at Massachusetts General Hospital in the United States. His research focuses on Alzheimer's disease, exploring therapeutic potentials of exercise hormones, specifically irisin, and investigating neurovascular dysfunction through engineered 3D models. His recent publications highlight key therapeutic targets and mechanisms, including the p38 MAPK-MK2 axis and the development of novel imaging radioligands.

Articles (20)

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2020

Collaborators (4)

Sharon Xiaolei Huang

Professor

The Pennsylvania State University - University Park Campus

UNITED STATES

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Claudio Vinegoni

Asst. Professor

Harvard University

UNITED STATES

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Cameron McAlpine

Associate Professor

Icahn School of Medicine at Mount Sinai

UNITED STATES

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Atsushi Anzai

Keio University

JAPAN

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Se Hoon Choi

Research Interests

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About

Articles (20)

Therapeutic potential of exercise-hormone irisin in Alzheimer’s disease

Therapeutic potential of exercise-hormone irisin in Alzheimer’s disease

Engineered 3D human neurovascular model of Alzheimer's disease to study vascular dysfunction

Integrative pathway analysis across humans and 3D cellular models identifies the p38 MAPK-MK2 axis as a therapeutic target for Alzheimer’s disease

Development of a New Positron Emission Tomography Imaging Radioligand Targeting RIPK1 in the Brain and Characterization in Alzheimer's Disease

Structure‐Based Discovery of A Small Molecule Inhibitor of Histone Deacetylase 6 (HDAC6) that Significantly Reduces Alzheimer's Disease Neuropathology

Irisin reduces amyloid-β by inducing the release of neprilysin from astrocytes following downregulation of ERK-STAT3 signaling

Accelerating the in vitro emulation of Alzheimer’s disease-associated phenotypes using a novel 3D blood-brain barrier neurosphere co-culture model

Adult neurogenesis in Alzheimer's disease

Adult hippocampal neurogenesis in Alzheimer’s disease: A roadmap to clinical relevance

Epitope alteration by small molecules and applications in drug discovery.

Development of a potential PET probe for HDAC6 imaging in Alzheimer's disease.

Natural medicine HLXL targets multiple pathways of amyloid-mediated neuroinflammation and immune response in treating alzheimer's disease.

Rapid Biomarker Screening of Alzheimer's Disease by Interpretable Machine Learning and Graphene-Assisted Raman Spectroscopy.

Degradation and inhibition of epigenetic regulatory protein BRD4 exacerbate Alzheimer's disease-related neuropathology in cell models.

Exercise hormone irisin is a critical regulator of cognitive function.

Astrocytic interleukin-3 programs microglia and limits Alzheimer's disease.

Molecular imaging of Alzheimer's disease-related gamma-secretase in mice and nonhuman primates.

Amyloid-β42/40 ratio drives tau pathology in 3D human neural cell culture models of Alzheimer’s disease

Upregulation of Alzheimer's Disease Amyloid-β Protein Precursor in Astrocytes Both in vitro and in vivo.

Collaborators (4)

Sharon Xiaolei Huang

Claudio Vinegoni

Cameron McAlpine

Atsushi Anzai

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