Sean Fanning

Assistant Professor

Loyola University Chicago

United States

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About

Sean Fanning is an Assistant Professor at Loyola University Chicago, United States. His research primarily focuses on the structural and functional aspects of estrogen receptors, including studies on isomer stereochemistry, receptor mutations, and novel therapeutic approaches targeting breast cancer. Recent publications highlight his work on the binding and activation mechanisms of estrogen receptor α and innovative strategies for targeting MYC in cancer therapy.

Articles (9)

Year:

2025

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2024

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2023

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2023

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2023

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2022

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2022

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UNITED STATES

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John Norris

Associate Research Professor

Duke University

UNITED STATES

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Darjan Duraki

University of Illinois at Urbana-Champaign

UNITED STATES

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Sean Fanning

Research Interests

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Articles (9)

Benzestrol Isomer Stereochemistry Determines the Distinct Estrogenic Activities and Conformations of the Eight Isomers When Bound to Estrogen Receptor α

Estrogen Receptor Alpha Mutations, Truncations, Heterodimers, and Therapies

Structural Determinants of the Binding and Activation of Estrogen Receptor α by Phenolic Thieno[2,3‐d]pyrimidines

Alternative activation

Targeting MYC with modular synthetic transcriptional repressors derived from bHLH DNA-binding domains

Unconventional isoquinoline-based SERMs elicit fulvestrant-like transcriptional programs in ER+ breast cancer cells

Labeling of a mutant estrogen receptor with an Affimer in a breast cancer cell line

Defining the Energetic Basis for a Conformational Switch Mediating Ligand-Independent Activation of Mutant Estrogen Receptors in Breast Cancer

A small-molecule activator of the unfolded protein response eradicates human breast tumors in mice

Collaborators (7)

Erik Nelson

Timothy Fan

Emad Tajkhorshid

Deborah Thomas

Shubin Liu

John Norris

Darjan Duraki

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